“
“P>Background: Two stage reconstructions of deep scalp wounds with exposed calvarial bone require a vital granulation tissue. By evaluating different surgical approaches functional and

cosmetic results as well as economic aspects have to be taken into account.

Patients and Methods: 52 patients undergoing three different surgical procedures for soft tissue reconstruction of complex scalp wounds with exposed bone were included into a retrospective study. All patients underwent a two stage procedure with 3D histologic control, soft tissue reconstruction and final split thickness skin grafting. Soft tissue reconstruction was carried out using allogenic fascia lata, an artificial Selleck BAY 57-1293 skin MS-275 substitute or a negative pressure wound therapy (NPWT). The costs

for all used materials as well as personnel and infrastructure were calculated.

Results: Comparing the costs for the different treatments, the fascia lata group was least costly (4,475 euro) followed by the artificial skin substitute group (4,557 euro). The highest expenses occurred in the NPWT group (7,.521 euro). The artificial skin substitute group had the fewest dressing changes and the shortest treatment time.

Conclusions: Although dermal regeneration templates are expensive, their use may be economic. NPWT causes high

treatment costs due to high daily rental rates and frequent and time-consuming dressing changes.”
“Background: Obstructive PD-1/PD-L1 targets sleep apnea has been associated with impaired endothelial function; however, the mechanisms underlying this association are not completely understood. Cell-derived microparticles may provide a link between obstructive sleep apnea and endothelial dysfunction. Objectives: This randomized controlled trial aimed to examine the effect of a 2-week withdrawal of continuous positive airway pressure (CPAP) therapy on levels of circulating microparticles. Methods: Forty-one obstructive sleep apnea patients established on CPAP treatment were randomized to either CPAP withdrawal (subtherapeutic CPAP) or continuing therapeutic CPAP, for 2 weeks. Polysomnography was performed and circulating levels of microparticles were analyzed by flow cytometry at baseline and 2 weeks. Results: CPAP withdrawal led to a recurrence of obstructive sleep apnea. Levels of CD62E+ endothelium-derived microparticles increased significantly in the CPAP withdrawal group compared to the continuing therapeutic CPAP group (median difference in change +32.4 per mu l; 95% CI + 7.3 to + 64.1 per mu l, p = 0.010).

The expression and secretion of the recombinant proteins were confirmed in vitro using immunofluorescence (IF) and western blot (WB) analyses. Human dengue immune serum samples recognized recombinant proteins. The immunogenicity of the 4 proteins in BALB/c mice was analyzed using ELISA, and the results revealed that the induced specific antibody response was higher in the groups of mice immunized with the P28 fusion proteins. Interestingly, although the 4 recombinant proteins selleckchem were able to elicit high levels of

neutralizing antibodies in BALB/c mice; no adjuvant effect was observed in terms of neutralizing antibodies in the groups immunized with proteins containing P28. Thus, ELISA and PRNT50 assays may evaluate different epitopes

and responses, where ELISA showed a wider response that did not always correlate with neutralization. Furthermore, the elicited antibodies were able to recognize the immobilized E glycoprotein of DENV. All mice vaccinated with the DENV-2 recombinant proteins showed induction of higher levels of IgG1 antibodies than of IgG2a antibodies.”
“Objective: To compare the efficacy of in situ transforming growth factor-betal (TGF-beta 1)-pretreated periosteum to untreated periosteum for regeneration of osteochondral tissue in rabbits.

Methods: In the pretreatment group, 12 month-old New Zealand white rabbits received subperiosteal Milciclib injections of 200 ng of TGF-beta 1 percutaneously in the medial side of the proximal tibia, 7 days prior to surgery. Control rabbits received no treatment prior surgery. Osteochondral transverse defects measuring 5 mm proximal to distal and spanning the entire width of the patellar groove BLZ945 were created and repaired with untreated or TGF-beta 1-pretreated periosteal grafts. Post-operatively the rabbits resumed normal cage activity for 6 weeks.

Results: Complete filling of the defects with regenerated

tissue was observed in both the TGF-beta 1 -pretreated and control groups with reformation of the original contours of the patellar groove. The total histological score (modified O’Driscoll) in the TGF-beta 1-pretreated group, 20(95% Confidence Interval (CI), 19-21), was significantly higher (P=0.0001) than the control group, 18 (16-19). The most notable improvements were in structural integrity and subchondral bone regeneration. No significant differences in glycosaminoglycan or type II collagen content, or equilibrium modulus were found between the surgical groups. The cambium of the periosteum regenerated at the graft harvest site was significantly thicker (P=0.0065) in the TGF-beta 1-pretreated rabbits, 121 mu m (94-149), compared to controls, 74 mu m (52-96), after 6 weeks.

Conclusions: This study demonstrates that in situ pretreatment of periosteum with TGF-beta 1 improves osteochondral tissue regeneration at 6-weeks post-op compared to untreated periosteum in 12 month-old rabbits. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Kinetic parameters, rate constants,

equilibrium sorption capacities, and related correlation coefficients for kinetic models were determined. It was found that the present system of cobalt adsorption on lemon peel adsorbent could be described more favorably by the pseudo-second-order kinetic model. The adsorption process has been found to be exothermic. The results of the present study suggest that lemon peel waste can be used beneficially in treating industrial effluents containing heavy metal ions. (C) 2009 Elsevier B.V. All rights reserved.”
“Theoretical efficiencies of a hot carrier solar cell considering indium nitride as the absorber material have been calculated in this work. In a hot carrier solar cell highly energetic carriers are extracted from the device before thermalisation, www.selleckchem.com/products/4-hydroxytamoxifen-4-ht-afimoxifene.html allowing higher efficiencies in comparison to conventional solar cells. Previous reports on efficiency calculations approached the problem using two different theoretical frameworks, the particle conservation (PC) model or the impact ionization model, which are only valid in particular extreme conditions. In addition MDV3100 mw an ideal absorber material with the approximation of parabolic bands has always been considered in the past. Such assumptions give an overestimation

of the efficiency limits and results can only be considered indicative. In this report the real properties of wurtzite bulk InN absorber have been taken into account for the calculation, including the actual dispersion

relation and absorbance. A new hybrid model that considers particle balance and energy balance at the same time has been implemented. Effects of actual impact ionization (II) and Auger recombination (AR) lifetimes have been included in the calculations for the first time, considering buy PF-02341066 the real InN band structure and thermalisation rates. It has been observed that II-AR mechanisms are useful for cell operation in particular conditions, allowing energy redistribution of hot carriers. A maximum efficiency of 43.6% has been found for 1000 suns, assuming thermalisation constants of 100 ps and ideal blackbody absorption. This value of efficiency is considerably lower than values previously calculated adopting PC or II-AR models. (c) 2010 American Institute of Physics. [doi:10.1063/1.3494047]“
“Methods: Patients with AF or atypical atrial flutter experienced SVC isolation. The junctional rhythm or sinus arrest could be observed, if sinus node was injured. Atropin and dopamine administration ruled out the vagal irritation of sinus node, when junctional rhythm or sinus arrest occurred.

Results: One hundred and thirty-two patients who had no electrocardiogram signs of sinus node dysfunction before ablation experienced the SVC isolation. Six patients (three men, three women, mean age 62.5 +/- 8.6 years) had sinus node injury (4.

025), after adjustment for maternal education, maternal BPb exposure, Home Observation for Measurement of the Environment Inventory (HOME), and gender of child, using linear mixed models. No significant relation was observed between prenatal and cord blood Pb levels and children’s cognitive function in children 2-8 years.

Conclusions: Low-level postnatal BPb levels in children at selleck inhibitor 2-5 years may have lagged effects on neurodevelopment in those at 5 to 8 years. Action is warranted to reduce even very low environmental

Pb levels to reduce the developmental burden of Pb on children. (C) 2011 Elsevier Ltd. All rights reserved.”
“Objective: alpha-klotho, a protein with anti-aging properties, has been involved in important biological processes, such as calcium/phosphate metabolism, resistance to oxidative stress, and nitric oxide production in the endothelium. Recent studies have suggested a role of alpha-klotho in endocrine regulation of mineral metabolism and postnatal growth in infants. Yet, the role of alpha-klotho during pregnancy remains largely unknown. The aim of this study was to determine whether maternal plasma concentration of alpha-klotho changes during pregnancy Sotrastaurin clinical trial and evaluate its expression in pregnancies complicated by small

for gestational age (SGA) and/or preeclampsia (PE).

Study design: This cross-sectional study included patients in the following groups: (1) non pregnant women (n = 37); (2) uncomplicated pregnancy (n = 130); (3) PE without an SGA neonate (PE; n = 58); (4) PE with an SGA neonate (PE and SGA; n=52); and (5) SGA neonate without PE (SGA; n = 52). Plasma concentrations of alpha-klotho were determined by ELISA.

Results: The median plasma alpha-klotho concentration was higher in pregnant than in nonpregnant women. Among women with an uncomplicated pregnancy, the median plasma concentration of alpha-klotho increased as a function of gestational age (Spearman Rho = 0.2; p = 0.006). The median (interquartile range) plasma concentration of alpha-klotho in women

with PE and SGA [947.6 (762-2013) pg/mL] and SGA without PE [1000 (585-1567) pg/mL] were 21% and 17% lower than that observed in women with an uncomplicated pregnancy [1206.6 (894-2012) pg/mL], (p = 0.005 and p = 0.02), respectively. Additionally, there were no significant Ion Channel Ligand Library differences in the median plasma concentration of alpha-klotho between uncomplicated pregnancies and women with PE without an SGA neonate (p = 0.5).

Conclusion: Maternal plasma concentration of alpha-klotho was higher during pregnancy than in a non-pregnant state. Moreover, the median maternal plasma concentration of alpha-klotho was lower in mothers who delivered an SGA neonate than in those with an uncomplicated pregnancy regardless of the presence or absence of PE.”
“BACKGROUND

Despite increasing awareness of and public attention to patient safety, little is documented about how adverse events (AEs) can or should be monitored in dermatologic surgery.

Individuals selleck chemicals llc who underwent bariatric surgery between 2004 and 2007 were recruited for inclusion in the study. The diagnosis of current and lifetime AUD and other Axis I disorders was assessed using the Structured Clinical Interview for DSM-IV.

A total of 51 individuals were included. The prevalence of lifetime and current AUD was 35.3% and 11.8%, respectively. No associations were found between weight loss following surgery and the development of an AUD or other Axis I diagnoses.

Significantly more current AUD was reported in (1) individuals with a lifetime history of AUD compared to those without a lifetime AUD (p < 0.05), and (2) individuals undergoing Roux-en-Y gastric bypass (RYGB) compared to those undergoing the laparoscopic adjustable gastric banding (LAGB) surgery (p < 0.05).

Individuals undergoing bariatric surgery were found to have a lifetime prevalence of AUD comparable to the general population. Although weight loss was not associated with the development of an AUD following surgery, individuals with a lifetime history of AUD may be at increased risk for relapsing to alcohol use after surgery.

All instances of current Ricolinostat chemical structure AUD were identified in individuals undergoing RYGB as opposed to LAGB.”
“Objective: To explore the evidence translation process during a 1-week national guideline development workshop (“”Child Health Evidence Week”") in Kenya.

Study Iressa Design and Setting: Nonparticipant observational study of the discussions of a multidisciplinary guideline development panel in Kenya. Discussions were aided by GRADE (Grading of Recommendations Assessment, Development, and Evaluation) grid.

Results: Three key thematic categories emerged: 1) “”referral to other evidence to support or refute the proposed recommendations;”" 2) “”assessment of the presented research evidence;”" and 3) “”assessment of the local applicability of evidence.”" The types of evidence cited included research evidence and anecdotal evidence

based on clinician experiences. Assessment of the research evidence revealed important challenges in the translation of evidence into recommendations, including absence of evidence, low quality or inconclusive evidence, inadequate reporting of key features of the management under consideration, and differences in panelists’ interpretation of the research literature. A broad range of factors with potential to affect local applicability of evidence were discussed.

Conclusion: The process of the “”Child Health Evidence Week”" combined with the GRADE grid may aid transparency in the deliberative process of guideline development, and provide a mechanism for comprehensive assessment, documentation, and reporting of multiple factors that influence the quality and applicability of guideline recommendations. (C) 2012 Elsevier Inc. All rights reserved.

(PACE 2009; 32:346-353).”
“Mutations in the MECP2 gene are found in a large proportion of girls with Rett Syndrome. Despite extensive research, the principal role of MeCP2 protein remains elusive. Is MeCP2 a regulator NVP-BSK805 purchase of genes, acting in concert with co-activators and co-repressors, predominantly as an activator

of target genes or is it a methyl CpG binding protein acting globally to change the chromatin state and to supress transcription from repeat elements? If MeCP2 has no specific targets in the genome, what causes the differential expression of specific genes in the Mecp2 knockout mouse brain? We discuss the discrepancies in current data and propose a hypothesis to reconcile some differences in the two viewpoints. Since transcripts from repeat elements contribute to piRNA biogenesis, we propose that piRNA levels may be higher in the absence of MeCP2 and that increased piRNA levels may contribute to the mis-regulation of some genes seen in the Mecp2 Avapritinib supplier knockout mouse brain. We provide

preliminary data showing an increase in piRNAs in the Mecp2 knockout mouse cerebellum. Our investigation suggests that global piRNA levels may be elevated in the Mecp2 knockout mouse cerebellum and strongly supports further investigation of piRNAs in Rett syndrome.”
“Nitrogen dioxide (NO2), a surrogate measure of traffic-related air pollution (TRAP), has been associated with incident childhood asthma. Timing of exposure and atopic status may be important effect modifiers. We collected cross-sectional data on asthma outcomes from Toronto school children aged 5-9 years in 2006. Lifetime home, school and daycare addresses were obtained to derive birth and cumulative NO2 exposures for a nested case-control subset of 1497 children. Presence of other allergic disease (a proxy for atopy) was defined as self-report of one or more of doctor-diagnosed rhinitis, eczema, or food allergy. Generalized estimating equations were used to adjust for potential confounders, and examine hypothesized effect modifiers while accounting for clustering by school. In children with other allergic disease, birth, cumulative and 2006 NO2 were associated with lifetime

asthma (OR 1.46, 4EGI-1 mouse 95% Cl 1.08-1.98; 1.37, 95% Cl 1.00-1.86; and 1.60, 95% Cl 1.09-236 respectively per interquartile range increase) and wheeze (OR 1.44, 95% Cl 1.10-1.89; 1.31, 95% Cl 1.02-1.67; and 1.60, 95% Cl 1.16-2.21). No or weaker effects were seen in those without allergic disease, and effect modification was amplified when a more restrictive algorithm was used to define other allergic disease (at least 2 of doctor diagnosed allergic rhinitis, eczema or food allergy). The effects of modest NO2 levels on childhood asthma were modified by the presence of other allergic disease, suggesting a probable role for allergic sensitization in the pathogenesis of TRAP initiated asthma. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

“
“Previously unknown diastereoisomeric sulfoxides were synthesized by asymmetric oxidation of 2-neomenthylsulfanyl-substituted 1H-imidazole, 1-methyl-1H-imidazole, and 1H-benzimidazole.”
“Alcohol withdrawal syndrome (AWS) continues to be a challenge to manage in the ICU setting, and the ideal pharmacological treatment

continues to evolve. Dexmedetomidine is a newer agent approved for short-term sedation in the ICU, but its use in the treatment of AWS has been limited. We report a retrospective case series of ten patients who were identified as receiving Selleckchem CX-4945 dexmedetomidine for AWS as designated by electronic pharmacy records. All subjects were male, with a mean age of 53.6 years, and a mean ICU length of stay of 9.3 days. They were all diagnosed with AWS by DSM-IV criteria. All the study patients received dexmedetomidine during their hospital course as a treatment for AWS. Studied variables included demographic data, dose and duration of dexmedetomidine, other pharmaceutical agents,

and hemodynamics. Dexmedetomidine was safe to use in all patients, although mechanical ventilation Selleck VS-4718 was still required in three patients. With dexmedetomidine, the autonomic hyperactivity was blunted, with a mean 12.8 % reduction in rate pressure product observed. Consideration should be given to the combined use of dexmedetomidine with benzodiazepines in the treatment of AWS.”
“Objectives: To investigate the efficacy of cochlear implants (CIs) in infants versus children operated at later age in term of spoken language skills and cognitive performances.

Method: The present prospective cohort study focuses on 19 children fitted with CIs between 2 and 11 months (X = 6.4 months; SD = 2.8 months). The results were compared with two groups of children implanted at 12-23 and 24-35 months. Auditory abilities were evaluated up to 10 years of Cl use with: Category of Auditory Performance (CAP); Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS); Peabody Picture

Vocabulary Test (PPVT-R); Test of Reception of Grammar (TROG) and Speech Intelligibility Rating (SIR). Cognitive evaluation was performed using selected subclasses from the Griffiths Mental Development Scale (GMDS, 0-8 Selleck OSI906 years of age) and Leiter International Performance Scale-Revised.(LIPS-R, 8-13 years of age).

Results: The infant group showed significantly better results at the CAP than the older children from 12 months to 36 months after surgery (p < .05). Infants PPVT-R outcomes did not differ significantly from normal hearing children, whereas the older age groups never reached the values of normal hearing peers even after 10 years of Cl use. TROG outcomes showed that infants developed significantly better grammar skills at 5 and 10 years of follow up (p < .001). Scores for the more complex subtests of the GMDS and LIPS-R were significantly higher in youngest age group (p < .

Journal of Human Hypertension ( 2009) 23, 794-800; doi: 10.1038/jhh.2009.20; published online 26 March 2009″
“The chemical constituents of the stems and twigs of Lindera umbellata were investigated, buy Mizoribine and a new lignan derivative and four known compounds were isolated. The structure of the new compound was established as (2S,3S)-2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-1,4-butanediol

1,4-diferulate on the basis of spectroscopic analysis and the result of alkaline methanolysis. The isolated compounds were evaluated for their scavenging effects on 1,1-diphenyl-2-picrylhydrazyl and O(2) (-) radicals.”
“P>The pentatricopeptide-repeat (PPR) protein DELAYED GREENING 1 (DG1) has been shown to be involved selleck kinase inhibitor in the regulation of early chloroplast development and chloroplast gene expression in Arabidopsis. To gain insight into the mode of DG1 action, we used a yeast two-hybrid screening approach and identified a partner, SIG6, which is a chloroplast sigma factor responsible for the transcription of plastid-encoded RNA polymerase (PEP)-dependent

chloroplast genes in cotyledons. Further analysis showed that the C-terminal region of DG1 and the N-terminal region of SIG6 are responsible for such interactions. High-level expression of a truncated C-terminal DG1 in wild-type Arabidopsis caused a dominant-negative phenotype. The sig6 dg1 double mutant displayed a more severe chlorotic phenotype, and the PEP-dependent chloroplast gene transcripts were greatly reduced compared with transcript levels in the single mutants. Overexpression of SIG6 rescued the chlorophyll deficiency in dg1 cotyledons but not in young leaves. In addition, increased SIG6 promoted PEP-dependent chloroplast gene transcript accumulation in the dg1 mutant background. These results

suggest that the interaction of DG1 and SIG6 is functionally significant Immunology & Inflammation inhibitor in the regulation of PEP-dependent chloroplast gene transcription in Arabidopsis cotyledons.”
“The predisposition to thrombogenesis is increased in essential hypertension, and hypertensive patients are prone to develop more vulnerable atherosclerotic plaques. To evaluate the possible influence of family history of hypertension on some indicators of early atherosclerosis, we studied eighty-five healthy normotensive individuals with (FH+) or without (FH-) family history of essential hypertension by measuring metabolic profile and concentrations of P-selectin, interleukin 6 and matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1. In a subset of individuals, MMP-9 activity was assessed in monocytes by zymography, and TIMP-1 expression by western blot. As compared with FH individuals, FH+ individuals had significantly higher P-selectin but similar interleukin-6 levels.

These experimental results can be explained by analytically calculating JNK-IN-8 manufacturer the anisotropic magnetoresistance effect induced by the motion of the vortex core. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3536390]“
“During investigations conducted within two years (2007 – 2009) 30 natural cenopopulations that were found, confirmed medicinal plants that can be used in the treatment of pediatric diseases. It was systematically studied life forms and distribution of 50 families, 94 genera and 97 species of medicinal

plants widely spread in Azerbaijan flora which are used in the treatment of pediatric diseases. It was determined that the majority of medicinal plants contains grasses (71%, 69 species). Among them, perennials are characterized with the highest number (48 species, 49.5%), annuals with medium (12 species, 12.4%) and biennials with the least number (9 species, 9.3%). Profoundly described plant resources and role in the medicine of species such as, Berberis vulgaris, Crataegus pentagyna,

Althaea officinalis, Hippophae 4SC-202 research buy rhamnoides, Inula helenium, Vaccinium myrtillis and Vaccinium vitis idaea detected and confirmed the area of distribution of medicinal plants, their vegetation phase and collected parts with priorities used in the treatment of pediatric diseases.”
“The present article endeavors to synthesize new polyamides via direct polycondensation of various diamines [hexamethylene diamine, rho-phenylene diamine, 2,5-bis(m-aminobenzylidene) cyclopentanone, and 2,6-bis (m-aminobenzylidene) cyclohexanone] with different bis (carboxy-substituted) hydrazines such as [1,2-bis(3-carboxy

click here acrylyl) hydrazine and 1,2-bis(3-carboxybenzoyl) hydrazine]. The polycondensation reaction of 1,2-bis(3-p-hydroxyanilide acrylyl) hydrazine with the same bis(carboxy-substituted) hydrazines gave polyester amides. The poly-condensation process was run in the presence of CaCl(2), triethylphosphite, and pyridine as a catalyst. These polymers were characterized by FTIR, (1)H-NMR, solubility, TGA, DSC, X-ray, mechanical properties, and electrical conductivity. The electrical conductivity measurements showed that all new polymers show promise as insulators. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 1152-1161, 2011″
“We present a new type of electro- and magneto-optical spatial light modulators (e-MOSLMs) utilizing the concept of photonic crystals (PCs) – such e-MOSLMs have a microcavity structure. They comprise a magneto-optical (MO) and electro-optical (EO) constituents that can control the direction of the polarization plane, when applying voltage and/or external magnetic fields. Optical spectra of e-MOSLMs were analyzed by using the matrix approach.

Similarly, one can also convert a flux relaxation process starting with an arbitrary internal field into a process starting with a melting internal field by introducing a virtual time interval. Therefore,

one can predict the melting internal field (or critical current density) from a flux relaxation process starting with a lower internal field. Finally, I show that the vortex penetration process in an ideal superconductor is strongly time dependent because of the surface barrier and internal field repulsive force. But the flux relaxation process does not occur in the ideal superconductor. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3590148]“
“Introduction Assisted reproductive technologies are increasingly more present in our everyday life: from classical sperm/egg 4-Hydroxytamoxifen donation or in vitro fertilization to newer, more controversial methods such as surrogate motherhood, male pregnancies or posthumous sperm procurement. Every year, new concepts are emerging in this field and the medical world is not always prepared to deal with them.

Material and method The greatest problem of using posthumous sperm procurement as an assisted reproductive method resides in analyzing consent related. An extensive research of the scientific literature revealed

eight possible situations which we will present and analyze in this article.

Results CX-4945 purchase By analyzing consent related issues we present a decision making algorithm for posthumous sperm procurement.”
“Background and aims: Oxidative stress has been advocated as a major cause for cardiovascular disease (CVD), and low plasma antioxidant concentrations are associated with endothelial dysfunction, the first step towards atherosclerosis. However, although the antioxidant content in fruits and vegetables may explain at least in part their protective effect against CVD, supplementation with antioxidant vitamins fails to improve endothelial function and reduce CVD risk. The aim of this study was to investigate the impact of a diet rich in antioxidants on endothelial function

measured by https://www.selleckchem.com/JNK.html flow-mediated dilatation (FMD) in volunteers at low cardiovascular risk.

Methods and results: In a crossover trial, 24 subjects (13 women, mean age 61 +/- 3 years), received, in a randomised order, a 14-day high (HT) and a 14-day low (LT) antioxidant diets, with a 2-week wash-out (WO) in between. Both diets were comparable in daily portions of fruits and vegetables, and in alcohol, fibre and macronutrient intake, but differed in their total antioxidant capacity. Before and after each diet, anthropometrics, blood pressure, fasting plasma glucose, lipid profile, hepatic enzymes, circulating antioxidant concentrations, high sensitivity C-reactive protein (hs-CRP) and FMD were assessed.

FMD increased significantly during the HT diet compared to the LT (p < 0.