Individuals selleck chemicals llc who underwent bariatric surgery between 2004 and 2007 were recruited for inclusion in the study. The diagnosis of current and lifetime AUD and other Axis I disorders was assessed using the Structured Clinical Interview for DSM-IV.

A total of 51 individuals were included. The prevalence of lifetime and current AUD was 35.3% and 11.8%, respectively. No associations were found between weight loss following surgery and the development of an AUD or other Axis I diagnoses.

Significantly more current AUD was reported in (1) individuals with a lifetime history of AUD compared to those without a lifetime AUD (p < 0.05), and (2) individuals undergoing Roux-en-Y gastric bypass (RYGB) compared to those undergoing the laparoscopic adjustable gastric banding (LAGB) surgery (p < 0.05).

Individuals undergoing bariatric surgery were found to have a lifetime prevalence of AUD comparable to the general population. Although weight loss was not associated with the development of an AUD following surgery, individuals with a lifetime history of AUD may be at increased risk for relapsing to alcohol use after surgery.

All instances of current Ricolinostat chemical structure AUD were identified in individuals undergoing RYGB as opposed to LAGB.”
“Objective: To explore the evidence translation process during a 1-week national guideline development workshop (“”Child Health Evidence Week”") in Kenya.

Study Iressa Design and Setting: Nonparticipant observational study of the discussions of a multidisciplinary guideline development panel in Kenya. Discussions were aided by GRADE (Grading of Recommendations Assessment, Development, and Evaluation) grid.

Results: Three key thematic categories emerged: 1) “”referral to other evidence to support or refute the proposed recommendations;”" 2) “”assessment of the presented research evidence;”" and 3) “”assessment of the local applicability of evidence.”" The types of evidence cited included research evidence and anecdotal evidence

based on clinician experiences. Assessment of the research evidence revealed important challenges in the translation of evidence into recommendations, including absence of evidence, low quality or inconclusive evidence, inadequate reporting of key features of the management under consideration, and differences in panelists’ interpretation of the research literature. A broad range of factors with potential to affect local applicability of evidence were discussed.

Conclusion: The process of the “”Child Health Evidence Week”" combined with the GRADE grid may aid transparency in the deliberative process of guideline development, and provide a mechanism for comprehensive assessment, documentation, and reporting of multiple factors that influence the quality and applicability of guideline recommendations. (C) 2012 Elsevier Inc. All rights reserved.