025), after adjustment for maternal education, maternal BPb exposure, Home Observation for Measurement of the Environment Inventory (HOME), and gender of child, using linear mixed models. No significant relation was observed between prenatal and cord blood Pb levels and children’s cognitive function in children 2-8 years.
Conclusions: Low-level postnatal BPb levels in children at selleck inhibitor 2-5 years may have lagged effects on neurodevelopment in those at 5 to 8 years. Action is warranted to reduce even very low environmental
Pb levels to reduce the developmental burden of Pb on children. (C) 2011 Elsevier Ltd. All rights reserved.”
“Objective: alpha-klotho, a protein with anti-aging properties, has been involved in important biological processes, such as calcium/phosphate metabolism, resistance to oxidative stress, and nitric oxide production in the endothelium. Recent studies have suggested a role of alpha-klotho in endocrine regulation of mineral metabolism and postnatal growth in infants. Yet, the role of alpha-klotho during pregnancy remains largely unknown. The aim of this study was to determine whether maternal plasma concentration of alpha-klotho changes during pregnancy Sotrastaurin clinical trial and evaluate its expression in pregnancies complicated by small
for gestational age (SGA) and/or preeclampsia (PE).
Study design: This cross-sectional study included patients in the following groups: (1) non pregnant women (n = 37); (2) uncomplicated pregnancy (n = 130); (3) PE without an SGA neonate (PE; n = 58); (4) PE with an SGA neonate (PE and SGA; n=52); and (5) SGA neonate without PE (SGA; n = 52). Plasma concentrations of alpha-klotho were determined by ELISA.
Results: The median plasma alpha-klotho concentration was higher in pregnant than in nonpregnant women. Among women with an uncomplicated pregnancy, the median plasma concentration of alpha-klotho increased as a function of gestational age (Spearman Rho = 0.2; p = 0.006). The median (interquartile range) plasma concentration of alpha-klotho in women
with PE and SGA [947.6 (762-2013) pg/mL] and SGA without PE [1000 (585-1567) pg/mL] were 21% and 17% lower than that observed in women with an uncomplicated pregnancy [1206.6 (894-2012) pg/mL], (p = 0.005 and p = 0.02), respectively. Additionally, there were no significant Ion Channel Ligand Library differences in the median plasma concentration of alpha-klotho between uncomplicated pregnancies and women with PE without an SGA neonate (p = 0.5).
Conclusion: Maternal plasma concentration of alpha-klotho was higher during pregnancy than in a non-pregnant state. Moreover, the median maternal plasma concentration of alpha-klotho was lower in mothers who delivered an SGA neonate than in those with an uncomplicated pregnancy regardless of the presence or absence of PE.”
“BACKGROUND
Despite increasing awareness of and public attention to patient safety, little is documented about how adverse events (AEs) can or should be monitored in dermatologic surgery.