A univariate

analysis showed that PCI was significantly related to education, PTSD symptoms (re-experience, avoidance, and hyperarousal), fatigue, depression, anxiety, and undergoing chemotherapy or radiotherapy. Hierarchical linear regression revealed that PTSD symptoms and fatigue (R-2=0.26, P smaller than 0.001) independently accounted for PCI in Chinese women with breast cancer regardless of age, education level, chemotherapy and radiotherapy. Hyperarousal was the only contributing PTSD symptom to PCI (B=-1.24, SE=0.33, =-0.39, P smaller than 0.001). ConclusionsBesides GSK3326595 chemotherapy, PTSD symptoms, especially hyperarousal, and fatigue are important risk factors for significant PCI and are therefore worthy of further investigation. Copyright (c) 2014 John Wiley & Sons, Ltd.”
“Garcia J. The calcium channel alpha(2)/delta(1) subunit interacts with ATP5b in the plasma

membrane of developing muscle cells. Am J Physiol Cell Physiol 301: C44-C52, 2011. First published April 13, 2011; doi:10.1152/ajpcell.00405.2010.-The alpha 2/delta Selleck GS 1101 1 and alpha(1)1.1 subunits are present at a 1: 1 ratio in the dihydropyridine receptor (DHPR) from adult skeletal muscle. In contrast, during early myotube development alpha 2/delta 1 is present at higher levels than alpha(1)1.1 and localizes at the ends of the cells, suggesting that alpha 2/delta 1 may have a role independent from DHPRs. We sought to identify binding partners of alpha 2/delta 1 at a period when levels of alpha(1)1.1 are low. Analysis of protein complexes in their native configuration established that alpha 2/delta 1 may be associating with ATP5b, a subunit of a mitochondrial ATP synthase complex. This interaction was confirmed with fluorescence resonance energy transfer and coimmunoprecipitation.

The association of alpha 2/delta 1 and ATP5b occurs in intracellular membranes and at the plasma membrane, where they form a functional signaling complex capable of accelerating the rate of decline of calcium transients. The acceleration of decay was more Selleckchem BLZ945 evident when myotubes were stimulated with a train of pulses. Our data indicate that the alpha 2/delta 1 subunit is not only part of the DHPR but that it may interact with other cellular components in developing myotubes, such as the ATP5b in its atypical localization in the plasma membrane.”
“Development of orange-fleshed sweetpotatoes (OFSP) is desired for the improvement of the food supply and nutritional status of millions of people in developing countries, particularly in sub-Saharan Africa. However, sweetpotato [Ipomoea batatas (L.) Lam] breeding is challenging due to its genetic complexity, and marker-assisted breeding tools are needed to facilitate crop improvement.

7 in the province where a devoted outpatient clinic is operated by nephrologists. (2) Prevalence of overt DN was 6% in our cohort, corresponding to 510 D1 patients worthy of evaluation for PT inside Emilia-Romagna region. (3) During 2006, UP/HR was 0.58 in Associazione

Inter-Regionale Trapianti agency, 1.16 in Tuscany, 0.30 in Piedmont, and 0.26 in our region. Taken together, our data showed that (1) the referral of D1 to PT has to be empowered, keeping in touch with all patients suffering from diabetic nephropathy; (2) the outpatient clinic devoted to evaluation and recruitment of D1 with nephropathy plays the key role in this program of timely and widespread referral; (3) the availability of pancreata can be increased by utilizing broader criteria for harvesting, increased consent rate to donation and increased the demand for PT (recipient pool). Pancreas grafts need to increase, since the current https://www.selleckchem.com/products/anlotinib-al3818.html low demand produces underutilization of the pancreas resource, due to the frequent lack of a suitable recipient.”
“The fishes are living in the medium rich in pathogenic microbes. The mucus secreted by the skin of fish showed more antimicrobial properties. The mucus collected from the two exotic fishes and

two indigenous fishes were tested against the five pathogenic bacteria Smad inhibitor (Klebsiella pneumonia, Vibrio cholerae, Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa) and five pathogenic fungi namely (Mucor globosus, Rhizopus arrhizus, Candida albicans, Aspergillus flavus and Aspergillus niger). The fishes are living in media rich in pathogenic microbes which secrete substances against them. The mucus secreted by the skin of fish showed more antimicrobial properties. More antibacterial and antifungal activity were observed in an indigenous fishes (Catla catla

and Labeo rohita) than exotic fishes (Hypophthalmichthys molitrix and Ctenopharyngodon idella).”
“This retrospective observational study was performed to determine the predictive value of midluteal serum progesterone measurement on the subsequent pregnancy outcome in women with unexplained Selleckchem NVP-AUY922 recurrent miscarriage after referral. This study involved women with unexplained recurrent miscarriage attending the recurrent miscarriage clinic between January 1992 and March 2011. A total of 132 women with unexplained recurrent miscarriage who conceived again within 12 months of midluteal serum progesterone measurement were analysed. Midluteal serum progesterone concentrations were compared between miscarriage and live birth groups. Also live birth rates were compared between higher and lower progesterone groups. Among 132 women studied, the serum progesterone concentrations (mean +/- SE) in the live birth group (n = 86) and miscarriage group (n = 46) were 42.3 +/- 2.4 nmol/l and 42.5 +/- 3.2 nmol/l, respectively.

8) and 1,2-cyclohexylenedinitrilotetraacetic acid (CyDTA) complexing agent, has been found to be at 576 nm (molar extinction coefficient, E: 36,750 +/- 240 L mol(-1) cm(-1)). Effects of various parameters like stability of complex, ethanol volume, ore matrix, interfering ions etc. on the

determination of uranium have also been evaluated. Absorbance measurements as a function of time showed that colored complex is stable up to >24 h. Presence of increased amount of ethanol in colored solution suppresses the absorption of a standard UO22+-Br-PADAP solution. Analyses of synthetic standard as well as ore leach a solution show that for 10 determination relative standard deviation (RSD) is <2%. The accuracy of the developed method has been checked by determining uranium using standard addition method and was found to be accurate with a 98-105% recovery Temsirolimus cost rate. The developed method has been applied for the analysis of a number of uranium samples generated from uranium ore leach solutions and results were compared with standard methods like inductively coupled plasma emission spectrometry (ICPAES).

The determined values of uranium concentrations by these methods are within +/- 2%. This method can be used to determine 2.5-250 mu g m L-1 uranium in ore leach solutions with high accuracy and precision. (C) 2012 Elsevier B.V. All rights P5091 supplier reserved.”
“We investigated female and male gamete formation in a pummelo [Citrus maxima (Burm.) Merr.] haploid. During female gamete selleck chemicals llc formation, no embryo-sac mother cell (EMC) was formed in ovules, and consequently no normal embryo sac was observed at anthesis, which was confirmed as the cause of female sterility in the haploid. During male gamete formation, on the other hand, meiosis in the pollen mother cells (PMCs) of the haploid occurred twice, but abnormalities were observed in most dividing cells. In some dividing

cells, univalents did not distribute to the opposite poles at anaphase I; instead, they remained near the equatorial plate. The nine univalents then performed mitosis, which distributed equally forward opposite poles. Furthermore, at the tetrad stage, the tetrad comprised 99.3% of the ‘Banpeiyu’ pummelo, whereas sporads from monads to hexads with a relatively high frequency of dyads (24.7%) were produced in the haploid. These results suggest that fertile pollen grains observed in the haploid pummelo were produced by abnormalities in the first meiotic division such as first division restitution (FDR).”
“Introduction The catheter ablation procedure is a minimally invasive surgery used to treat atrial fibrillation. Difficulty visualizing the catheter inside the left atrium anatomy has led to lengthy procedure times and limited success rates.

Thirty-six tumors from 33 patients (mean age: 60.4, range: 26 to 88; 17 men and 16 women) were studied. Three patients had bilateral tumors and 1 patient had von Hippel-Lindau disease. Follow-up was available in 60% (20/33) of the patients for a mean of 27.4 (range 1 to 85) months. No patient had evidence of the disease after surgery except for the patient with von Hippel-Lindau disease, who was alive with stable disease in the contralateral kidney. All 36 tumors were small (mean size 2.4 cm; range 0.9 to 4.5 cm) and low stage (pT1). The majority was cystic and had prominent fibrous capsule and stroma. The tumors were composed of variable amount of cysts, papillae,

tubules, acini, and solid nests. The most characteristic histologic features were branching tubules and acini and anastomosing clear cell ribbons

with low-grade nuclei. All tumors were strongly positive for selleck products CK7 and variably positive for CA9, but largely negative for CD10, and negative for alpha-methylacyl-CoA racemase and TFE-3. All but 1 tumor had no gains of GTPL8918 chromosomes 7 and 17 and deletion of 3p. Only 1 tumor had low copy number gains of chromosomes 7 and 17. VHL gene mutation and promoter methylation were negative in 2 tumors analyzed. We show that these tumors, which we term as “clear cell tubulopapillary renal cell carcinoma,” constitute a unique subtype in the spectrum of renal epithelial neoplasia based on their characteristic morphologic and immunohistochemical features.”
“Adult lymphoblastic lymphoma (LBL) is

an aggressive form of non-Hodgkin lymphoma occurring in predominantly adolescent and young adult men. Lymphoblastic lymphoma is rare, accounting for 1% to 2% of all non-Hodgkin lymphomas and is of T-cell phenotype in 90% of cases. Lymphoblastic lymphoma is morphologically indistinct from acute lymphoblastic leukemia (ALL). Both express their lineage-specific markers as well as terminal deoxynucleotidyl transferase. The differences are often made on clinical grounds. Lymphoblastic lymphoma is characterized by a predominantly nodal distribution of disease, often with a large mediastinal mass. Patients with less than 25% bone marrow involvement have typically been categorized as LBL rather than ALL, although this has not been applied consistently in the literature. Gene expression studies have identified differences in gene expression, 17DMAG with LBL expressing higher levels of genes associated with cytoskeleton, adhesion, angiogenesis, and chemotaxis than ALL. Although LBL and ALL can be distinct clinically, chemotherapy strategies are often very similar. Acute lymphoblastic leukemia regimens, which incorporate intensive multidrug induction, consolidation, delayed intensification, and maintenance, have been shown to be superior to standard lymphoma regimens. As central nervous system (CNS) relapse is common, CNS prophylaxis with high-dose chemotherapy and intrathecal therapy is also standard.

Chelating intracellular Ca2+ or abrogating CaMKK-beta function by gene silencing or chemical inhibition prevented the CO(2)-induced

AMPK activation in AECs. Activation of AMPK or overexpression of constitutively active AMPK was sufficient to activate PKC-zeta and promote Na,K-ATPase endocytosis. Inhibition or downregulation of AMPK via adenoviral delivery of dominant-negative AMPK-alpha(1) prevented CO(2)-induced Na,K-ATPase endocytosis. The hypercapnia effects were independent of intracellular ROS. Exposure of rats to hypercapnia for up to 7 days caused a sustained decrease in AFR. Pretreatment with a beta-adrenergic agonist, isoproterenol, or a cAMP analog www.selleckchem.com/products/kpt-8602.html ameliorated the hypercapnia-induced impairment of AFR. Accordingly, we provide evidence that elevated CO(2) levels are sensed by AECs and that AMPK mediates CO(2)-induced Na,K-ATPase endocytosis and alveolar epithelial dysfunction, which can be prevented with beta-adrenergic agonists and cAMP.”
“Background: In adults, heart rate recovery is a predictor of mortality, while in adolescents it is associated

with cardio-metabolic risk factors. The aim of this study was to examine the relationship between body composition measures and heart rate recovery (HRR) after step test in Malaysian secondary selleck inhibitor school students.\n\nMethods: In the Malaysian Health and Adolescents Longitudinal Research Team (MyHEART) study, 1071 healthy secondary school students, aged 13 years old, participated in the step test. Parameters for body composition measures were body mass index z-score, body fat percentage, waist circumference, and waist height ratio. The step test was

conducted by using a modified Harvard step test. Heart rate recovery of 1 minute (HRR1min) and heart rate recovery of 2 minutes (HRR2min) were calculated www.selleckchem.com/products/gsk1838705a.html by the difference between the peak pulse rate during exercise and the resting pulse rate at 1 and 2 minutes, respectively. Analysis was done separately based on gender. Pearson correlation analysis was used to determine the association between the HRR parameters with body composition measures, while multiple regression analysis was used to determine which body composition measures was the strongest predictor for HRR.\n\nResults: For both gender groups, all body composition measures were inversely correlated with HRR1min. In girls, all body composition measures were inversely correlated with HRR2min, while in boys all body composition measures, except BMI z-score, were associated with HRR2min. In multiple regression, only waist circumference was inversely associated with HRR2min (p=0.024) in boys, while in girls it was body fat percentage for HRR2min (p=0.008).\n\nConclusion: There was an inverse association between body composition measurements and HRR among apparently healthy adolescents. Therefore, it is important to identify cardio-metabolic risk factors in adolescent as an early prevention of consequent adulthood morbidity.

\n\nResults: A total

of 174 patients with a mean age of 62.7 years were included in analysis. At hospital 1 a mean of 16 lymph nodes were found after dissection vs a mean of 28 reported at hospital 2 (p <0.001). No significant differences were found in the number of tumor positive lymph nodes (p = 0.65). Mean lymph node density at hospitals 1 and 2 was 9.3% and 3.9%, respectively (p = 0.056).\n\nConclusions: Despite equal anatomical clearance by the same experienced surgeons we report a statistically significant difference between 2 pathology departments where the number of lymph nodes was evaluated after extended bilateral pelvic lymph node dissection for bladder cancer. Unless standardized methods are agreed on by pathologists, the number of reported lymph

nodes as an indicator of surgical quality and lymph AZD1208 manufacturer node density as a prognostic factor should be used cautiously.”
“The sample frequency spectrum of a segregating site is the probability distribution of a sample of alleles from a genetic locus, conditional on observing the sample to be polymorphic. This distribution is widely used in population genetic inferences, including statistical tests of neutrality in which a skew in the observed frequency spectrum across independent sites is taken Epigenetic signaling inhibitor as a signature of departure from neutral evolution. Theoretical aspects of the frequency spectrum have been well studied and several interesting results are available, but they are usually under the assumption that a site has undergone at most one mutation event in the history of the sample. Here, we extend previous theoretical results by allowing for at most two mutation events per site, under a general finite allele model in which the mutation rate is independent of current allelic state but the transition matrix is otherwise completely arbitrary. Our results apply to both nested and nonnested mutations. Only the former has been addressed previously, whereas here we show it is the latter that is more likely to be observed except for very small sample sizes. Further, for any mutation transition matrix, we obtain the

joint sample Roscovitine solubility dmso frequency spectrum of the two mutant alleles at a triallelic site, and derive a closed-form formula for the expected age of the younger of the two mutations given their frequencies in the population. Several large-scale resequencing projects for various species are presently under way and the resulting data will include some triallelic polymorphisms. The theoretical results described in this paper should prove useful in population genomic analyses of such data. (c) 2011 Elsevier Inc. All rights reserved.”
“The freshwater planarian is a powerful animal model for studying regeneration and stem cell activity in vivo. During regeneration, stem cells (neoblasts in planarian) migrated to the wounding edge to re-build missing parts of the body.

\n\nIn this review, we

will take a historical view and highlight some of the milestones that had an important impact on the development of gene therapy. We will also discuss briefly the safety and ethical aspects of gene therapy and address some concerns that have been connected with gene therapy as an important therapeutic modality. (C) 2013 Elsevier B.V. All rights reserved.”
“In vitro antiplasmodial activity of methanolic extracts of 16 medicinal plants was evaluated by fluorometric assay using PicoGreen. CT99021 The IC50s, as determined by parasite DNA concentration, ranged from < 11 to > 200 and < 13 to > 200 mu g/ml for Plasmodium falciparum 3D7 and K1, respectively; and the most active extracts were those from Anogeissus leiocarpus and Terminalia avicennoides (< 11->= 14 mu g/ml). Aqueous, butanolic, ethyl acetate, and methanolic fractions of these two extracts revealed butanolic fraction to have a relatively better activity (IC50, 10-12 mu g/ml). Activity-guided chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by nuclear magnetic resonance P5091 molecular weight and correlation high-performance liquid chromatography revealed the presence of

known hydrolysable tannins and some related compounds-castalagin, ellagic acid, flavogallonic acid, punicalagin, terchebulin, and two other fractions. The IC(50)s of all these compounds ranged between 8-21 mu g/ml (8-40 mu M) against both the strains. Toxicity assay with mouse fibroblasts showed all the extracts and isolated compounds to have IC50 >= 1500 mu g/ml, except for Momordica balsamina with < 1500 mu g/l. All the extracts and isolated compounds did not affect the integrity of human erythrocyte membrane at the observed IC(50)s. However, adverse effects manifest in a concentration-dependent fashion (from IC50 >= 500 mu g/ml).”
“We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified

27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted SYN-117 chemical structure rats and which could be related with the greater longevity in these animals.”
“Inhibition of blood vessel formation is a viable therapeutic approach in angiogenesis-dependent diseases. We previously used a combinatorial screening on vascular endothelial growth factor (VEGF)activated endothelial cells to select the sequence CPQPRPLC and showed that the motif Arg-Pro-Leu targets VEGF receptor-1 and neuropilin-1. Here, we evaluated and validated (D)(LPR), a derivative molecule with strong antiangiogenesis attributes. This prototype drug markedly inhibits neovascularization in three mouse models: Matrigel-based assay, functional human/murine blood vessel formation, and retinopathy of prematurity.

05). Reported VAS regarding pain from epidural puncture was lower PD-1/PD-L1 Inhibitor 3 chemical structure in Groups IA and Ib. Patients’ satisfaction was greater with parecoxib

in comparison with placebo.\n\nConclusion: The levels of anxiety have been investigated in several medical procedures and early, in the study of pain. The higher the expectation of pain and the anxiety are, the higher the intensity of the pain. Parecoxib seems to exert positive influence on pain and anxiety levels of interventional procedure. Further studies are needed to elucidate the actual mechanisms that are involved.”
“Chemo- and regio-selective epoxide phenolysis is reported for the first time under neutral condition catalysed by silver nanoparticles. Other metal nanoparticles (e.g., Au, Pd, Cu, In, and Ru) are less effective. The choice of solvent is critical with 2-propanol being the best followed by DEF. Amongst various stabilisers used (surfactants, PEGs, tetra-allcylammonium halides) the tetra-alkylammonium halides Selleckchem Rabusertib are found to be the most effective (TBAF bigger than TBAB bigger than TBACl bigger than TBAI). The role of the silver nanoparticles is envisaged as synchronous mode epoxide-phenol dual activation via a cooperative network of coordination, anion-it interaction, and hydrogen bond. The silver nanoparticles are recovered and reused for five consecutive times. The reaction has been used for the synthesis of

propranolol and naftopidil as a few representative cardiovascular drugs. (C) 2014 Published by Elsevier B.V.”
“The metallo-beta-lactamases (M beta Ls), which

require one or two Zn(II) ions in their active sites for activity, hydrolyze the amide bond in S-lactam-containing antibiotics, and render the antibiotics inactive. All known M beta Ls contain a mobile element near their active sites, and these mobile elements have been implicated in the catalytic mechanisms of these enzymes. However little is known about the dynamics of these elements. In this study, we prepared a site-specific, double spin-labeled analog of homotetrameric M beta L L1 with spin labels at positions 163 and 286 and analyzed the sample with DEER (double electron electron resonance) spectroscopy. Four unique distances were observed in the DEER distance distribution, and these distances were assigned Selleck Panobinostat to the desired intramolecular dipolar coupling (between spin labels at positions 163 and 286 in one subunit) and to intermolecular dipolar couplings. To rid the spin-labeled analog of L1 of the intermolecular couplings, spin-labeled L1 was “diluted” by unfolding/refolding the spin-labeled enzyme in the presence of excess wild-type L1. DEER spectra of the resulting, spin-diluted enzyme revealed a single distance corresponding to the desire intramolecular dipolar coupling. (C) 2014 Elsevier Inc. All rights reserved.”
“Papillary muscle rupture is now a rare complication of acute myocardial infarction.

“
“Transcription factor Histone Nuclear Factor P (HiNF-P; gene symbol Hinfp) mediates cell cycle

control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin. The HiNF-P/p220(NPAT) complex controls multiple H4 genes in established human cell lines and is critical for cell proliferation. The mouse Hinfp(LacZ) null allele causes early embryonic lethality due to a blastocyst defect. However, neither Hinfp function nor its temporal expression relative to histone H4 genes during fetal development has been explored. Here, we establish that expression of Hinfp is biologically coupled with expression of twelve functional mouse H4 genes during pre- and post-natal tissue-development. Both Hinfp and H4 genes are robustly expressed at multiple embryonic (E) days (from E5.5 to E15.5), coincident with ubiquitous LacZ staining driven by the Hinfp promoter. www.selleckchem.com/products/PLX-4032.html Five highly expressed mouse H4 genes (Hist1h4d, Histh4f, Hist1h4m GSK923295 manufacturer and Hist2h4) account for >90% of total histone H4 mRNA throughout development. Post-natal expression of H4 genes in mice is most evident in lung, spleen, thymus and intestine, and with few exceptions (e.g., adult liver) correlates with Hinfp gene expression. Histone H4 gene expression decreases but Hinfp levels remain constitutive upon cell growth inhibition in culture. The in vivo co-expression

of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development. (C) 2011 Elsevier B.V. All rights reserved.”
“Metabolic activation of new chemical entities to reactive intermediates is routinely monitored in drug discovery and development. Reactive intermediates may bind to cellular macromolecules such as proteins, DNA and may eventually lead to cell death via necrosis, apoptosis or oxidative stress. The evidence that the ultimate outcome of metabolic activation is an adverse drug reaction manifested as in vivo

toxicity, is at best circumstantial. However, understanding the process of bioactivation of structural alerts by trapping the reactive intermediates is critical to guide medicinal chemistry efforts in quest for safer and potent molecules. This commentary provides a brief introduction to adverse drug Liproxstatin-1 reactions and mechanisms of reactive intermediate formation for various functional groups, followed by a review of chemical design approaches, examples of such strategies, possible isosteric replacements for structural alerts and rationalization of laboratory approaches to determine reactive intermediates, as a guide to today’s medicinal chemist.”
“The development of alternative, non-fluorinated membranes for polymer electrolyte membrane fuel cells necessitates the co-development of a non-fluorinated electrode catalyst binder to ensure compatibility between membrane and electrode.

ON cone bipolar cell axonal ribbons drive bistratified ONOFF ganglion cells in the OFF layer and provide ON drive to polarity-appropriate targets such as bistratified diving ganglion cells (bsdGCs). The targeting precision of find more ON cone bipolar cell axonal synapses shows that this drive incidence is necessarily

a joint distribution of cone bipolar cell axonal frequency and target cell trajectories through a given volume of the OFF layer. Such joint distribution sampling is likely common when targets are sparser than sources and when sources are coupled, as are ON cone bipolar cells. J. Comp. Neurol. 521:9771000, 2013. (c) 2012 Wiley Periodicals, Inc.”
“Background: Because breast cancer is a major public health issue, it is particularly important to measure the quality of the care provided to patients. Survival LY294002 PI3K/Akt/mTOR inhibitor rates are affected by the timeliness of care, and waiting times constitute key quality criteria. The aim of this study was to develop

and validate a set of quality indicators (QIs) relative to the timeliness and organisation of care in new patients with infiltrating, non-inflammatory and metastasis-free breast cancer undergoing surgery. The ultimate aim was to use these QIs to compare hospitals.\n\nMethods: The method of QI construction and testing was developed by COMPAQ-HPST. We first derived a set of 8 QIs from consensus guidelines with the aid of experts and professional associations and then tested their metrological properties in a panel of 60 volunteer hospitals. We assessed feasibility using a grid exploring 5 dimensions, discriminatory power using the Gini coefficient as a measure of dispersion, and inter-observer reliability using the Kappa coefficient.\n\nResults: Overall, 3728 records were included in the analyses. All 8 QIs showed acceptable feasibility (but one QI was subject to misinterpretation), fairly strong agreement between observers (Kappa = 0.66), and wide variations in implementation among hospitals (Gini coefficient < 0.45 except for QI 6 (patient information)). They are thus suitable

for use to compare hospitals and measure quality improvement.\n\nConclusions: Of the 8 QIs, 3 are ready for nationwide implementation (time 3-Methyladenine PI3K/Akt/mTOR inhibitor to surgery, time to postoperative multidisciplinary team meeting (MDTM), conformity of MDTM). Four are suitable for use only in hospitals offering surgery with on-site postoperative treatment (waiting time to first appointment after surgery, patient information, time to first postoperative treatment, and traceability of information relating to prognosis). Currently, in the French healthcare system, a patient receives cancer care from different institutions whose databases cannot as yet be easily merged. Nationwide implementation of QIs covering the entire care pathway will thus be a challenge.”
“Synchronous bronchial carcinoid tumor and giant bullae are rare entities. In this article, we report a 62-year-old male presenting with dyspnea, cough and chest pain.