analysis showed that PCI was significantly related to education, PTSD symptoms (re-experience, avoidance, and hyperarousal), fatigue, depression, anxiety, and undergoing chemotherapy or radiotherapy. Hierarchical linear regression revealed that PTSD symptoms and fatigue (R-2=0.26, P smaller than 0.001) independently accounted for PCI in Chinese women with breast cancer regardless of age, education level, chemotherapy and radiotherapy. Hyperarousal was the only contributing PTSD symptom to PCI (B=-1.24, SE=0.33, =-0.39, P smaller than 0.001). ConclusionsBesides GSK3326595 chemotherapy, PTSD symptoms, especially hyperarousal, and fatigue are important risk factors for significant PCI and are therefore worthy of further investigation. Copyright (c) 2014 John Wiley & Sons, Ltd.”
“Garcia J. The calcium channel alpha(2)/delta(1) subunit interacts with ATP5b in the plasma
membrane of developing muscle cells. Am J Physiol Cell Physiol 301: C44-C52, 2011. First published April 13, 2011; doi:10.1152/ajpcell.00405.2010.-The alpha 2/delta Selleck GS 1101 1 and alpha(1)1.1 subunits are present at a 1: 1 ratio in the dihydropyridine receptor (DHPR) from adult skeletal muscle. In contrast, during early myotube development alpha 2/delta 1 is present at higher levels than alpha(1)1.1 and localizes at the ends of the cells, suggesting that alpha 2/delta 1 may have a role independent from DHPRs. We sought to identify binding partners of alpha 2/delta 1 at a period when levels of alpha(1)1.1 are low. Analysis of protein complexes in their native configuration established that alpha 2/delta 1 may be associating with ATP5b, a subunit of a mitochondrial ATP synthase complex. This interaction was confirmed with fluorescence resonance energy transfer and coimmunoprecipitation.
The association of alpha 2/delta 1 and ATP5b occurs in intracellular membranes and at the plasma membrane, where they form a functional signaling complex capable of accelerating the rate of decline of calcium transients. The acceleration of decay was more Selleckchem BLZ945 evident when myotubes were stimulated with a train of pulses. Our data indicate that the alpha 2/delta 1 subunit is not only part of the DHPR but that it may interact with other cellular components in developing myotubes, such as the ATP5b in its atypical localization in the plasma membrane.”
“Development of orange-fleshed sweetpotatoes (OFSP) is desired for the improvement of the food supply and nutritional status of millions of people in developing countries, particularly in sub-Saharan Africa. However, sweetpotato [Ipomoea batatas (L.) Lam] breeding is challenging due to its genetic complexity, and marker-assisted breeding tools are needed to facilitate crop improvement.