PubMedCrossRef 24. Dittmann K, Mayer C, Kehlbach R, Rodemann HP: Radiation-induced caveolin-1 associated EGFR internalization Belnacasan is linked with nuclear EGFR transport and AZD6738 manufacturer activation of DNA-PK. Mol Cancer 2008, 7:69.PubMedCrossRef 25. Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, et al.: Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 2006,8(12):1359–1368.PubMedCrossRef 26. Linggi B, Carpenter G: ErbB

receptors: new insights on mechanisms and biology. Trends Cell Biol 2006,16(12):649–656.PubMedCrossRef 27. Li C, Iida M, Dunn EF, Ghia AJ, Wheeler DL: Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene 2009,28(43):3801–3813.PubMedCrossRef 28. Wang YN, Yamaguchi H, Hsu JM, Hung MC: Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene 2010,29(28):3997–4006.PubMedCrossRef

29. Han W, Lo HW: Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer Lett 2012,318(2):124–134.PubMedCrossRef MCC950 supplier 30. Santarius T, Shipley J, Brewer D, Stratton MR, Cooper CS: A census of amplified and overexpressed human cancer genes. Nat Rev Cancer 2010,10(1):59–64.PubMedCrossRef 31. Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC: Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 2005,7(6):575–589.PubMedCrossRef 32. Hsiao JR, Jin YT, Tsai ST, Shiau AL, Wu CL, Su WC: Constitutive Tyrosine-protein kinase BLK activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. Br J Cancer 2003,89(2):344–349.PubMedCrossRef 33. Ting CM, Wong CK, Wong RN, Lo KW, Lee AW, Tsao

GS, Lung ML, Mak NK: Role of STAT3/5 and Bcl-2/xL in 2-methoxyestradiol-induced endoreduplication of nasopharyngeal carcinoma cells. Mol Carcinog 2011,51(12):963–972.PubMedCrossRef 34. Wang Z, Luo F, Li L, Yang L, Hu D, Ma X, Lu Z, Sun L, Cao Y: STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. Eur J Cancer 2010,46(16):2996–3006.PubMedCrossRef 35. Liu YP, Tan YN, Wang ZL, Zeng L, Lu ZX, Li LL, Luo W, Tang M, Cao Y: Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Int J Mol Med 2008,21(2):153–162.PubMed 36. Gu Y, Zhang S, Wu Q, Xu S, Cui Y, Yang Z, Zhao X, Sun B: Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer. J Exp Clin Cancer Res 2010, 29:6.PubMedCrossRef 37. Peschos D, Stefanou D, Vougiouklakis T, Assimakopoulos DA, Agnantis NJ: Cell cycle proteins in laryngeal cancer: role in proliferation and prognosis. J Exp Clin Cancer Res 2005,24(3):431–437.PubMed 38.