Liver is the most frequent metastatic site of neuroendocrine carcinomas. Thus, differential diagnosis between PHNECs and metastatic hepatic neuroendocrine carcinomas is Inhibitor Library ic50 very important for the diagnosis of PHNECs. Methods: Case description: We presented a 38 year-old lady with an advanced PHNEC. She initially complained of frequent watery diarrhea and vomiting for 5 months. There was associated rapid weight loss of more than 15 kg. Clinical examination revealed gross liver enlargement. CT scan of the abdomen showed multiple heterogenous liver
lesions involving both lobes. The largest was in segment VIII measuring 15.0 cm × 11.2 cm. There was no other lesion in other organs or lymphadenopathy noted. Tumour markers and hepatitis serology
were normal. Results: Liver biopsy performed showed features consistent with neuroendocrine tumour. They were positive for synaptophysin and chromagranin; and negative for CK20, CK7, CEA, TTF1 and alpha fetoprotein. Subsequent PET CT showed exclusive somatostatin receptor avid disease in the liver with no extrahepatic foci. Unfortunately, the lesions were too extensive and surgical resection was not an option. She was started on Octeotride 50 mcgs tds. Her symptoms significantly improved. Subcutaneous injection Octeotride LAR 30 mg monthly was successively given. After 6 months, repeated abdominal CT scan showed considerable reduction in numbers and size of the PHNEC. Conclusion: We Dactolisib nmr illustrated the importance
of prompt identification and diagnosis for PHNECs to initiate proper treatment regimen for the patient. Key Word(s): 1. hepatic neuroendocrine carcinoma; 2. diagnosis; 3. treatment; 4. octreotide Presenting Author: JU SEOK KIM Additional Authors: HEE SEOK MOON, SEOK HYUN KIM Corresponding Author: JU SEOK KIM Affiliations: Chungnam National University College of Medicine, Chungnam National University MCE College of Medicine Objective: Introduction: Leiomyosarcoma is an uncommon tumor that originates from various organs, including the uterus and kidney, as well as the retroperitoneum and soft tissues. In particular, leiomyosarcoma of the stomach are extremely rare. Only 9 cases have been reported worldwide since the discovery of KIT-activating mutation. In contrast to many cases of GIST, the leiomyosarcoma is rare in the stomach and has higher mitotic activity and a worse prognosis. We present a rare case of gastric leiomyosarcoma with multiple metastasis involving lymph nodes. Case Report: A 48-year-old woman was admitted to our hospital with abdominal discomfort and general weakness. Upon detection of multiple nodules in both lungs on chest PA performed at the time of admission, chest CT was performed, which revealed masses in the lung, liver, and pancreas, with multiple lymph node metastases. In addition, an endoscopic examination revealed about 1.