In situation (b) a second absence due to CMD occurs > 28 days after return to work. We define this situation as recurrent sickness absence due to CMD. As in situation a, the person-years are counted from the beginning of the first episode of sickness absence due

to CMDs until the end of the employment period. In situation (c) there is a second episode of absence due to CMDs within 28 days after return to work, which is not counted as a recurrence. In the example, the employee is employed during the entire period. In situation (d) there is an episode of sickness absence due to CMDs lasting more than 1 year. The person-years are counted until 1 year of sickness absence. Fig. 1 Calculation of recurrence NU7026 solubility dmso density of sickness absence due to common mental disorders The RD of sickness absence due to CMDs in the diagnostic JQ-EZ-05 in vivo categories was calculated by dividing the number of employees with recurrent sickness absence due to CMDs by the person-years at risk in the Luminespib manufacturer diagnosis-specific subpopulations, irrespective of the duration of the episodes. For example: the RD of recurrent sickness absence due to CMDs was assessed in the subpopulation of employees with a previous episode of sickness absence due to adjustment disorders. We distinguished between recurrent sickness absence due to the same type of mental disorder (adjustment disorder in the example) and recurrent sickness absence due to other types of

mental disorders. Determinants Gender, age (<35, 35–44, 45–54 and ≥55 years), marital status (married/not married), duration of employment (0–4 years, 5–9 years, 10–14 years, 15–19 years and ≥20 years), type of employment (full-time/part-time) and company (Post/Telecommunication)

were included as determinants. In 2001, the gross monthly salary scales (1–2, 3, 4–5, 6–7, ≥8) in the Post and Telecommunication companies ranged from EUR 1,656 (scale 2), 1,813 (scale 3), 2,029 (scale 5), 2,395 (scale 7) to EUR 2,675 (scale 8). Statistical analysis The duration and time-to-onset of recurrent sickness absence due to CMDs was computed in months using Kaplan–Meier survival analysis. Kaplan–Meier survival analysis allows estimation of duration times and comparison of duration times between groups, even when employees are studied for different lengths Unoprostone of time. We define a rate as the sum of persons with recurrent sickness absence due to CMDs (same or other mental disorder) per unit exposure time. Not all employees are observed for the same length of time. We model counts per unit exposure time, and in our analysis person-years are handled as exposure time. We performed a log-rate analysis with this rate as dependent variable, and initial diagnosis, age, full-time/part-time, marital status, salary scale, employment characteristics and company as explaining variables. The results are presented as rate ratios (RR) with 95% confidence intervals (CI).