The first is on Mechanisms of Gastrointestinal and Liver Diseases, the second is about Advances in Clinical Practice. The first review articles in these new series are both about irritable bowel syndrome. That in the Mechanisms of Disease series written by Ghoshal and colleagues canvasses the potential roles of gut infections and microbiotica,2 whereas that by Gibson and Shepherd discusses the Advances in Clinical Practice afforded by consideration of food (specifically FODMAP) sensitivity.3 Hereafter, one article from each series will appear in most issues of the Journal. While the Editors take responsibility for developing suitable

topics and inviting authors to write these reviews, we would be interested to hear from you, our readers, on your ideas for topics that should be covered in the Asia–Pacific

region. In addition to making the Journal more efficient, more readable and more effective as a vehicle for promoting Asia–Pacific science BIBW2992 research buy and the practice of gastroenterology and hepatology, we are also making it more accessible. Specifically, most subscriptions to JGH are now electronic ones, submission and review are entirely electronic processes, and we have recently taken the decision to increase the content available for download free of charge. This now includes all editorial content (Table of Contents, Editorials, In this Issue, Images of Interest and Education), and all review articles, including meta-analyses, miniseries reviews and the selleck inhibitor new series mentioned earlier. From this issue, it will also include a selected number

(four to six per issue) of what we perceive to be our most exciting original articles, corresponding to those selected for comment in In This Issue. The occasion of our 25th Anniversary in December 2010 will also be marked by a Silver Jubilee supplement; this will accompany the first issue of 2011 (Volume 26 : 1). We have invited 20 or so of our most successful authors of the last 25 years, whose articles rank at the top of our most cited ever, to write thought-provoking reviews of past, present and future developments in their field. We anticipate that this will allow us to compile an incredibly stimulating and readable Supplement. With all these improvements and exciting developments, we hope not to be two, well before we turn Casein kinase 1 30! But only you, the authors, can determine how much our reputation, utility and impact factor can improve by sending us some of your best articles to publish in JGH. Working with a panel of editors who are regional leaders in their countries and fields, together with our expanded panel of approximately100 Editorial Board Members, we hope to promote the further growth and development of our great twin specialities in this important Asia–Pacific part of the world. “
“We read with great interest the article by Tanaka et al.1 showing high serum levels of tauro-β-muricholic and taurocholic acid in two animal models of nonalcoholic steatohepatitis (NASH).