aim of


aim of GSK2245840 treatment of established osteoporosis is to maintain and, ideally, to restore bone strength with the ultimate goal of preventing fractures. There are currently a number of FDA-approved agents for the treatment of osteoporosis including bisphosphonates (e.g., alendronate, ibandronate, or risedronate), raloxifene, teriparatide, and calcitonin. Estrogen replacement therapy is indicated for the prevention of osteoporosis. All of these agents have been shown to increase BMD and several have shown efficacy in fracture risk reduction [6]. Thus, drug therapy is a key therapeutic component in preventing osteoporosis fractures in patients at risk for fracture. However, it is estimated that only 36% of women with buy Linsitinib post-menopausal osteoporosis

are treated with any agent for the prevention or treatment of osteoporosis, and specifically, only 16% were treated with bisphosphonate or calcitonin [7]. A number of studies have examined predictors of treatment to help understand what factors clinicians are weighting most heavily in determining whether to treat osteoporotic patients. Ideally, predictors of treatment should mirror predictors of fracture. Surprisingly, many of these studies have found that this is not necessarily the case. Increased age, oral corticosteroid usage, and smoking status are all risk factors for osteoporosis and fracture [8] but have often been found to have either a negative association or no association with treatment administration [9–20]. Yet several studies have found that either older patients are less likely to get treatment [12, 18, 22] or there is no association between age and treatment [20, 23].Low T-scores on BMD tests are strong predictors of fracture but are often not available

for researchers. In this study, we distinguish osteoporotic patients based on having a fracture or having a low BMD T-score or a diagnosis code for osteoporosis. Few studies have examined factors Dichloromethane dehalogenase associated with treatment in patients with these specific characteristics [11, 21]. As noted, the risk of fracture increases with age. The objective of this study was to identify predictors of osteoporosis treatment. This was done separately for two subgroups of osteoporosis patients: (1) those with a fracture (FRAC group) (2) and those with either an International Classification of Diseases (ICD)-9 code for osteoporosis and/or a low (≤−2.5) T-score from a BMD test (ICD-9-BMD group). Potential predictors were included based on their association with bone health and fall risk. The evaluated predictors included weight, body mass index (BMI), smoking status, excessive alcohol consumption, a history of previous fractures, BMD T-score, comorbid conditions, and drug exposures. In this study, we focused specifically on prescribing for oral bisphosphonates (risedronate, alendronate, and ibandronate).

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