Summary and conclusions Assessment of neuropsychological functions greatly broadens the understanding of schizophrenia. In this paper, we have summarized the evidence for cognitive impairments in schizophrenia, and for methods of assessment. One of the main incentives for understanding the signature of cognitive impairment in schizophrenia is the strong relationship between cognitive

performance and functional skills and functional outcome.85 For this, Inhibitors,research,lifescience,medical cognitive impairment may be the most relevant aspect of the illness. We are only beginning to understand the role of specific cognitive functions in different aspects of outcome,86 and better characterization of fundamental impaired cognitive processes is critical. Additionally, cognitive functioning may be used as a vulnerability marker.87,88 Cognitive impairments are proving to be one of the symptoms

within a cluster that may eventually Inhibitors,research,lifescience,medical enhance the ability to determine who is at risk of devel oping a psychotic disorder, and, in those already ill, may provide a prognostic marker for future functional outcome.2 Hence the importance of assessing and understanding Inhibitors,research,lifescience,medical the cognitive impairment in schizophrenia.
The last decade has seen striking progress in our understanding of the epidemiology of schizophrenia. Some traditional beliefs have been confirmed, but others have been swept away, while recent data have implicated new risk factors for the disorder and have changed the way we conceptualize it. Descriptive epidemiology Inhibitors,research,lifescience,medical Lifetime prevalence Schizophrenia affects just under 1% of the population at some point in their life. Perhaps the most comprehensive study to demonstrate this comes from Finland; Perala et al estimated lifetime prevalence, PF-02341066 research buy according to DSM-IV criteria, at 0.87% for schizophrenia, and 0.32% for schizoaffective disorder.1 Incidence For many years the Inhibitors,research,lifescience,medical curious view held sway that the incidence of schizophrenia was constant both geographically and temporally2 However, we now know that this is not so.3,4 A systematic review5 showed that rates for the incidence

of schizophrenia ranged from 7.7 to 43.0 per 100 000, a fivefold difference. There are fewer data concerning long-term trends, but it has been demonstrated that the operationally defined incidence of schizophrenia in South London whatever doubled between 1965 and 1997.6 Age of onset Kirkbride et al assessed the incidence of psychosis in three English cities as part of the large AESOP (Aetiology and Ethnicity of Schizophrenia and Other Psychoses) study. Figure 1 shows the age-specific incidence rates for psychosis as a whole and for the main diagnostic types. It can be seen (Figure 1c) that the peak incidence for schizophrenia in males was between 20 and 24 years, but 29 to 32 years in females; the latter showed a flatter curve with more cases presenting in later life.7 Thus, the AESOP study confirms previous evidence of an earlier age of schizophrenia onset in males.