Sample sizes were calculated by using the Minitab statistical package software (Release 14). This study was conducted via retrospective assessment of hospital records of the adult patients who were operated for acute appendicitis in Baskent University, Konya Research and Application Center, Vadimezan between January 2010 and February 2013 and had a pathology report that confirmed the diagnosis of acute appendicitis.

A total of 590 patients were included in the AA group. The patients in the control group were selected from healthy adults of similar Caspase Inhibitor VI order age who applied to check-up clinic and had no active complaint, chronic disease, or abnormal physical examination. Age, gender, leukocyte count, and selleck chemicals CRP and RDW levels were recorded. This study is a case controlled retrospective clinical study. Laboratory measurements WBC counts were determined using an electronic cell counter (Cell-Dyne 3700, Abbott, Abbott Park, IL, USA). Serum CRP levels were measured by spectrophotometric methods (Abbott Aeroset, Tokyo, Japan). The expected RDW values in our laboratory ranged between 11.6% and 15.5%. Statistical analysis Statistical analyses were performed with SPSS software. The groups were compared using

the t test for continuous variables and chi-square test for categorical variables. Mann–Whitney U test was used to compare nonhomogeneous groups in pairs. A simple correlation test (Spearman’s test) was used to observe the correlation between the RDW and other variables. Numeric values were expressed as means ± SD. A P value less than .05 was considered statistically significant. Results A total of 590 patients were included in the AA group and 121 patients were included in the control group, making up a total of 711 subjects. No significant difference was observed between the AA and control groups with respect to age and gender p > 0.05 (Table 1). The mean leukocyte count was 13.5 ± 4.5 (×103/mm3) in the AA group and 7.5 ± 2 (×103/mm3) in the control group. The leukocyte

count was significantly higher in the AA group (p < 0.001). The mean CRP Amino acid level was 48.8 ± 73.6 mg/dL in the AA group and 4.6 ± 4.7 mg/dL in the control group. CRP level in the AA group was significantly higher compared with the control group (p < 0.001). The mean RDW level was 15.4 ± 1.5% in the AA group and 15.9 ± 1.4% in the control group. RDW level was significantly lower in the AA group compared with the control group (p = 0.001) (Table 1). Receiver operating characteristic curve analysis suggested that the best cutoff point for RDW in the diagnosis of AA was 15.6%, which had a sensitivity of 47% and a specificity of 67%, (area under curve [AUC]: 0,62; Figure 1). Receiver operating characteristic curve analysis suggested that the best cutoff point for leukocyte count in the diagnosis of AA was 10.