Reversibility to bronchodilation (BD) testing is a functional characteristic of asthma. Objective. The aim of this study was to evaluate whether FeNO may predict reversibility to BD in a pediatric cohort of allergic subjects with asthma (180) or rhinitis (150). Methods. Lung function (including forced expiratory volume at the first second (FEV1), forced volume capacity (FVC), forced expiratory
flow at 25-75% of volume capacity (FEF (25-75))), FeNO measurement, and BD testing were performed in all children. Results. Lung function, FeNO, and sensitization type were significantly different in the two groups. A strong correlation was found between FeNO and Delta FEV1 after BD. Two main predictors of reversibility were FeNO values >34 ppb [Odds RatioAdj (ORAdj) = 1.9] and sensitization to selleck products perennial allergens (ORAdj = 1.7). Conclusions. This study provided evidence that FeNO was strongly related with the response to BD testing and could predict bronchial reversibility in children with allergic rhinitis or asthma. Therefore, a simple FeNO measurement could suggest relevant information about bronchial reversibility.”
“Hypothesis: The aim of this investigation was to define the expression of neurotrophic receptors within see more the developing inner
ear of different postnatal ages.
Background: Pattern of differential expression of neurotrophic receptors provide molecular target sites for multifunctional nanoparticle-based
cell-specific therapeutics delivery to treat hearing diseases.
Methods: Protein expression of neurotrophic receptors was studied by immune-histochemistry, quantitative polymerase chain reaction, in situ hybridization, Western blot, in early and late postnatal, adult, and aging mice.
Results: There was a high correlation between Navitoclax results obtained at ribonucleic acid and protein levels. TrkB and TrkC gene expression increased during the first 2 weeks and also after the onset of hearing in adult mice. At the onset of hearing, TrkB-immunopositive staining occurred in inner hair cells and in cell bodies of spiral ganglion neurons. TrkC was detected in nerve endings beneath inner and outer hair cells and in supporting cells. Root cells within the spiral ligament and spiral ganglion neurons in the Rosenthal’s canal showed high level of TrkC expression. p75NTR was found in organ of Corti similar to TrkC, and scattered neurons showed strong immunoreactivity in the Rosenthal’s canal. PD540 mice, a model of age-related hearing loss, showed a complete spiral ganglion cell loss in the basal turn. Although TrkB and TrkC were completely lacking in this region of the Rosenthal’s canal, remaining nerve fibers were p75NTR immunopositive.
Conclusion: We found differential expression pattern of TrkB, TrkC, and p75NTR receptors in the inner ear and could make a receptor expression data base.