Results:
A high expression of WISP-1 was observed in 26 of the 86 cases of EEC (30.2%). The expression rate of WISP-1 in EEC was significantly higher than that in secretory endometrium (P < 0.005). Histopathological grades and PR were associated with high WISP-1 expression (P = 0.002, P = 0.027, respectively). The
estimated five-year survival rate TH-302 molecular weight of patients with low-to-moderate expression of WISP-1 was significantly higher than those with high WISP-1 expression (91.3% vs 65%, P = 0.011). Multivariate analysis revealed that high WISP-1 expression and positive lymphovascular space invasion were independent prognostic factors for survival.
Conclusions:
High expression of WISP-1 was related to tumor cell dedifferentiation and PR loss. WISP-1 might be a new molecular marker to predict the prognosis of patients with EEC.”
“The structures of condensed tannin from Pinus brutia bark were characterized by means of GC-MS, solid and liquid state C-13 NMR and MALDI-TOF MS analyses. The results indicated that the monomeric units building up the condensed tannin of brutia pine bark are mainly composed of catechin/epicatechin, gallocatechin/epigallocatechin
units accompanied by possibly tri- or tetra hydroxyl-flavanols. Some oligomers appear to present p-hydroxy- or 3,4-dihydroxy benzoic acid residues or glucose at their terminal 3-MA ic50 unit. Apart from oligomers, monomeric flavanoids were also present in the brutia bark extract. Taxifolin was especially found in appreciable amounts. Additionally, in this tannin procyanidin oligomers predominated while prodelphinidin units were present to a lesser extent. The NMR results showed that the oligomers in brutia pine bark tannin Exhibit 2,3-cis stereochemistry and C4-C6 bonds with a noticeable portion of C4-C8 interflavonoid links being present. The MALDI-TOF MS showed a series of peaks corresponding to flavonoid hexamers of the condensed tannin (1750 Da). (C) 2013 Elsevier B.V. All rights reserved.”
“BACKGROUND: Apolipoprotein A-V (ApoA-V) has been shown to play an important role in the selleck screening library metabolism of plasma triglyceride (TG) levels. However, data for the relationship between serum ApoA-V and TO level and the
association between ApoA-V levels and the risk of coronary artery disease (CAD) are inconsistent.
OBJECTIVE: To investigate plasma ApoA-V level and its association with TG in patients with CAD determined by angiography.
METHODS: Three hundred forty subjects who underwent coronary angiography (CAG) were classified into a CAD group (n = 211) and a non-CAD group (n = 129) according to the results of their CAG. Serum ApoA-V levels were determined by enzyme-linked immunosorbent assays.
RESULTS: Patients in the CAD group had greater ApoA-V levels than controls (192.0 +/- 114.6 ng/mL vs 164.4 +/- 107.5 ng/mL, P < .05). The concentration of ApoA-V was positively correlated to TO level (r = 0.229, P < .01). This correlation was more intense in non-CAD group (r = 0.