Record in patient’s notes of HLA-B*57:01 status before starting ABC.

For the ‘which NRTI backbone’ and ‘which third Selleckchem RGFP966 agent’ questions, evidence profiles and summary of findings tables were constructed to assess quality of evidence across predefined treatment outcomes (Appendices 3 and 4). Evidence from RCTs and systematic reviews was identified from a systematic literature review (Appendix 2). Outcomes were scored and ranked (critical, important, not important) by members of the Writing Group. The following were ranked as critical outcomes: viral suppression at 48/96 weeks, protocol-defined virological failure, drug resistance, quality of life, discontinuation for adverse events and grade 3/4 adverse events (overall), rash and alanine transaminase/aspartate transaminase

elevation. Treatments were compared and differences in critical outcomes assessed. Where there were differences, consensus opinion was sought to determine whether the difference in size of effect was above the threshold for clinical decision-making. If conflicting differences were detected, the balance of outcomes was based on consensus opinion of the Writing Group. A treatment was defined as preferred or alternative to indicate strong or conditional recommendations Selleck VE822 and the decision based on the assessment of critical outcomes and the balance of desirable and undesirable effects in a general ART-naïve patient population. ‘Preferred’ indicates a strong recommendation that most clinicians and patients would want to follow unless there is a clear rationale not to do so. ‘Alternative’ indicates a conditional recommendation and is an acceptable treatment option for some patients and might be, in selected patients, the preferred

option. Factors including potential side effects, co-morbidities, Nintedanib research buy patient preference and drug interactions need to be taken into account when selecting an ART regimen in individual patients, and may include both preferred and alternative treatment options. For guidance on assessment of patients before initiation of ART and monitoring of patients on ART the reader should consult the BHIVA guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals 2011 [1]. We recommend therapy-naïve patients start combination ART containing TDF and FTC as the NRTI backbone (1A). We suggest ABC and 3TC is an acceptable alternative NRTI backbone in therapy-naïve patients who, before starting ART, have a baseline VL≤100 000 copies/mL (2A). ABC must not be used in patients who are HLA-B*57:01 positive (1A). Three RCTs have compared TDF-FTC with ABC-3TC as the NRTI backbone in combination with different third agents: ATV/r or EFV [2-6], EFV [7-9] and LPV/r [10]. Assessment of virological efficacy as a critical outcome was complicated by different definitions across the three studies. In our analysis for GRADE (see Appendix 3.