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“Rationale Methamphetamine (METH) induces hyperthermia, which is diminished with chronic treatment in a dose-dependent manner. Our CFTRinh-172 ic50 objective was to determine whether the temperature responses produced by a chronic, escalating-dose
METH regimen and a chronic, 5.0 mg/kg dose regimen.
Methods Rats received pretreatment injections of saline, 5.0 mg/kg METH, 10.0 mg/kg METH (second comparison group), or an escalating-METH regimen (2-9 mg/kg) for 12 days. On day 13, all four groups were challenged with 10.0 mg/kg METH. Temperature measurements were made telemetrically at 24 degrees C ambient temperature.
Results Escalating pretreatment produced hyperthermia; with successive exposures, the hyperthermic peak shifted to the right. The 5.0-mg/kg-pretreatment group initially showed no change in temperature at 60 min post-treatment but developed hypothermia at 60 min with chronic treatment; at 3 h post-treatment, Barasertib price significant hyperthermia was
present and did not diminish with chronic treatment. After the 10.0-mg/kg-METH challenge, the saline-pretreatment group was hyperthermic, and the 10.0-mg/kg-pretreatment group was hypothermic; the 5.0 mg/kg and escalating pretreatment groups were intermediate and were not different from each other. At 3 h post-challenge, no group differences were apparent. Dopamine (DA) and serotonin (5-HT) were not depleted when measured 2 weeks after treatment ended.
Conclusions (1) FGFR inhibitor Escalating and 5.0-mg/kg regimens produced different temperature profiles during the 12-day pretreatment period but a similar diminished response to the 10.0-mg/kg-METH challenge on day 13. (2) The diminished temperature responses with chronic treatment occurred in the absence of long-term DA and 5-HT depletions.”
“BACKGROUND: Optimal management of bilateral vertebral artery dissecting aneurysms (bi-VDAs) causing subarachnoid hemorrhage (SAH) remains unclear.
OBJECTIVE: To investigate the treatment methods and outcomes of bi-VDA causing SAH.
METHODS: Seven patients were treated endovascularly for bi-VDA causing SAH. Treatment methods and outcomes were evaluated retrospectively.
RESULTS:
Two patients were treated with 2 overlapping stents for both ruptured and unruptured VDAs, 2 with 2 overlapping stents and coiling for ruptured VDA and with conservative treatment for unruptured VDA, 1 with internal trapping (IT) for ruptured VDA and stent-assisted coiling for unruptured VDA, 1 with IT for ruptured VDA and 2 overlapping stents for unruptured VDA, and 1 with IT for ruptured VDA and a single stent for unruptured VDA. None had rebleeding during follow-up (range, 15-48 months). All patients had favorable outcomes (modified Rankin Scale score, 0-2). On follow-up angiography at 6 to 36 months, 9 treated and 2 untreated VDAs revealed stable or improved state, whereas 3 VDAs in 2 patients showed regrowth.