Pediatr Dermatol 2001,18(2):163 PubMedCrossRef 27 Hwang JY, Lee

Pediatr Dermatol 2001,18(2):163.PubMedCrossRef 27. Hwang JY, Lee SW, Lee SM: The common ultrsonographic features of pilomatricoma. JUltrasound Med 2005,24(10):1397. 28. Whittle C, Martinez W, Baldassare G, Smoje G, Bolte K, Busel D, González S: Pilomatrixoma: ultrasound diagnosis. Rev Med Chil 2003,131(7):735.PubMed 29. Buchwald

HJ, Spraul CW, Kampmeier J, Lang GK: Ultrasound biomicroscopy in eyelid lesions – a clinical study in 30 patients. Klin Monatsbl Augenheilkd 2002, 219:95.PubMedCrossRef 30. Choo HJ, Lee SJ, Lee YH, Lee JH, Oh M, Kim MH, Lee EJ, Song JW, Kim SJ, Kim DW: Pilomatricomas: PSI-7977 the diagnostic value of ultrasound. Skel Radiol 2010, 39:243–250.CrossRef 31. Ackerman AB, De Viragh PA, Chongchitnant N: Neoplasm with follicular differentiation. Lea &Febiger, Philadelphia 1993, cap 21:477. Competing interests The authors declare that they have no competing interests. Authors’ contributions FE and AD carried out the research, participated in the sequence alignment and drafted the manuscript text. CP and AA assessed the pathological diagnosis. ADC contributed

with his professional experience to the revision of the manuscript. FMS conceived the study, participated in its design, carried out the research and coordinated the study. All authors read and approved the final manuscript.”
“Introduction Colorectal cancer (CRC) is the check details third most either common malignancy in the world. Colorectal carcinogenesis has been conceptualized as a multi-step, multi-mechanism process, consisting of an initiation, promotion and progression phase, which developed via a progressive accumulation of genetic mutations. Understanding the neoplastic progression of CRC at the cellular and molecular levels can facilitate diagnosis and treatment of cancer. Our lab has been devoted to research on the molecular mechanism of CRC for decades of years. In 1999, we separated the insulin-like growth factor binding protein 7 (IGFBP7) cDNA fragments from colonic adenocarcinoma and normal mucosa cDNA subtraction

libraries by suppressive subtractive hybridization (SSH)[1]. IGFBP7 was cloned as a senescence-associated gene from human mammary epithelial cells[2], also named as insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1)[3], meningioma associated cDNA 25 (MAC25)[2, 4], tumor-derived adhesion factor(TAF)[5], and prostacylin-stimulating factor(PSF)[6]. After the separation of IGFBP7, we then devoted to elaborate the biological role of the protein in CRC. Our group presented evidence that reintroduction of IGFBP7 suppressed the proliferation, decreased the colony formation ability, and induced apoptosis in two colorectal carcinoma cell lines RKO and SW620[7]. IGFBP7 protein could induce G1 cell cycle arrest in RKO and CW2 cells. A senescence-like phenotype was induced by IGFBP7 in these colon cancer cells[8].

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