It should be stressed that locally advanced oropharyngeal cancer tumors of the III-IV phases ended up being 1st analysis in 82.9% of patients. It could be as a result of low level suspicion of main attention doctors. The paper considers risk factors for growth of oropharyngeal cancer tumors and provides the menu of compulsory diagnostic tests. The authors suggest that recommended diagnostic algorithm will likely be beneficial to a timely recognition of precancer and cancer tumors abnormalities when you look at the oropharynx so that you can reduce the time also to establish the perfect scheduling of study of someone in specific healthcare facilities for very early detection of cancer.Transplantation of person internal organs is followed closely by the risk of the following event of a malignant neoplasm. The increased occurrence of malignant neoplasms is due to immunosuppressive treatment, which leads to impaired protected surveillance for malignant neoplasms, in addition to increased susceptibility to oncogenic viruses. We have not discovered a description for the laryngeal cancer tumors development after heart transplantation when you look at the available literature. Listed here is our observation. Individual P., 66 yrs . old, was accepted to your division of head and neck tumors of this State medical Hospital # 1 on 05/27/19 with complaints of hoarseness. Based on the evaluation, the analysis of laryngeal cancer cT3N0M0M was established. Anamnesis revealed that due to ischemic cardiomyopathy, post-infarction mitral insufficiency, balloon angioplasty and stenting of the right coronary artery on 17.08.11 and 06.11.13, orthotonic heart transplantation was performed. The medical situation was talked about with mutual participation of oncologists, radiologists, chemotherapists – a combined plan for treatment was created with preoperative radiotherapy of complete focal dosage (TFD) 44Gy at the first phase, which was carried out with minor good dynamics, followed by laryngectomy. The individuality of the observance is based on the reality that someone 6 many years after heart transplantation was identified as having laryngeal cancer, he underwent combined treatment HIV phylogenetics with neoadjuvant radiation therapy, TFD 44 Gy and a procedure in the volume of laryngectomy without complications. The optimal indicators and adequate criteria for the quantitative assessment of hearing loss extra danger with noise exposure above 80 dBA is urgently needed dedication. The technology for calculating hearing thresholds according to your model of the next edition of this ISO 1999.32013 standard, based on gender, age, duration of solution and sound visibility, according to MSExcell tables, for population percentiles 1÷99% in 1% measures is developed. Rules for deciding ideal indicators and criteria for reading Sputum Microbiome loss for the early signs of hearing loss extra risk as well as the excess danger of occupational noise-induced hearing loss happen developed. The extra danger of hearing check details reduction for men from the age, length of solution and the degree of noise exposure dependences tend to be computed. The suitable signs and requirements for hearing loss to identify very early signs and symptoms of the effect of sound regarding the hearing organ and also to calculate the excess threat of reading loss when confronted with noise are identified. Determined by the typical binaural hearing threshold at frequencies of 0.5; 1.0; 2.0 and 3.0 kHz with an 30 dB assessment criterion excess risk most properly solves the risk of occupational hearing reduction deciding problem. For the determine of very early signs and symptoms of hearing reduction extra threat the common binaural threshold for reading at frequencies of 4 and 6 kHz with an evaluation criterion of 20 dB is useful better.Computed by the average binaural hearing threshold at frequencies of 0.5; 1.0; 2.0 and 3.0 kHz with an 30 dB assessment criterion excess risk many adequately solves the possibility of occupational hearing reduction deciding issue. For the determine of very early signs of reading loss excess danger the common binaural limit for hearing at frequencies of 4 and 6 kHz with an evaluation criterion of 20 dB is beneficial better. The purpose of our research was an experimental evaluation of tissue manufacturing approach to chronic tympanic membrane perforation closure. Chronic tympanic membrane perforation designs were developed both edges in 12 chinchillas. Appropriate sided perforations were divided into two equal teams (A and B) relating to treatment; left-sided perforations were utilized as a control team. Group A perforations had been addressed with collagen scaffold and fibroblast development factor, team B perforations had been addressed with collagen scaffold only. During follow-up, we offered otovideoendoscopy for closing prices assessement every two weeks. In the event of perforation closure, a morphological investigation associated with the regenerate had been done. Group A perforations were totally shut 2 days after therapy in all pets. In group B, full closure of perforation ended up being attained following the 3rd treatment procedure within one situation. There have been no natural perforation closure in the control group.