Nonetheless, the effects of fishing were considered to be currently increasing and driving continuing Deterioration in condition in the Best10% of the SW and Worst10% XL184 ic50 of the E region. About 84% of the scores assigned to the impacts of pressures were considered to have either a High or Medium level of

confidence (Fig. 3b). This was the dominant pattern in the E and SE regions, where no pressure scores were assigned with Low confidence. In contrast, almost half of the pressure estimates assigned for the NW region were graded as Low in confidence. A similar pattern emerged for confidence in the pressure trends, although the trends in the SW were assigned with mainly Medium confidence, and in the N region

with mostly Low confidence (Fig. 3d). Cluster analysis of the full dataset (all regions, all components, all indicator data for condition, trends, confidence and pressures) distinguished the N region from the SE region at a high level in the classification, and these are separate from the E region and from the SW and NW regions (Fig. 4a). This cluster pattern reflects the substantive spatial differences in biodiversity and ecosystem health condition, pressures, information quality (based on confidence grades), this website and trends across the national jurisdiction. The primary separation of the groups in this cluster is driven by differences in condition and trend in habitats and a number of species groups, and by differences in confidence. The subset of data containing biodiversity and ecosystem health components that occur and were scored in more than one region (21 habitats; 31 species Isotretinoin and species groups; 17

ecological processes; 17 physical and chemical processes; and 5 PIDA components – see Supplementary Material) show similar spatial and temporal patterns to those identified in the overall dataset. The uniqueness and group fidelity of conditions and trends for the biodiversity and ecosystem health components from each individual region are highlighted by the cluster analysis (Fig. 4b). The biodiversity and ecosystem health components occurring in 2 or more regions and found to be in worst condition (pooled indicators median score = 5 or less, Poor) include 10 species or species groups, 2 habitats, a physical process (condition of the East Australian Current) and an ecological process (trophic structure and relationships). The Poor condition of 10 of these 14 components is related to fishing or hunting pressures, some of which are historic and date to more than a century ago (such as hunting of fur seals) (Table 5).