Nature 2003, 426:194–198.CrossRef 14. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614–636.PubMedCrossRef 15. Hayflick L, Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res 1961, 25:585–621.PubMedCrossRef A-1210477 16. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J: Retinoblastoma-protein-dependent

cell-cycle inhibition by the tumour suppressor p16. Nature 1995, 375:503–506.PubMedCrossRef 17. Stein GH, Drullinger LF, Soulard A, Dulic V: Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999, 19:2109–2117.PubMed 18. Vaziri H, West MD,

Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S: ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 https://www.selleckchem.com/products/XAV-939.html protein involving poly(ADP-ribose) polymerase. The EMBO journal 1997, 16:6018–6033.PubMedCrossRef 19. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA: Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406:641–645.PubMedCrossRef 20. Artandi SE, DePinho RA: A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev 2000, 10:39–46.PubMedCrossRef www.selleckchem.com/products/tpx-0005.html 21. Rudolph KL, Millard M, Bosenberg MW, DePinho RA: Telomere

dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 2001, 28:155–159.PubMedCrossRef 22. Horikawa I, Barrett JC: Cis-activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. J Natl Cancer Inst 2001, 93:1171–1173.PubMedCrossRef 23. Liu H, Shi W, Luan F, Xu S, Yang F, Sun W, Liu J, Ma C: Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. Virus Genes 2010, 40:174–182.PubMedCrossRef 24. Qu ZL, Zou SQ, Cui NQ, Wu XZ, Qin MF, Kong D, Zhou ZL: Upregulation of human telomerase reverse transcriptase mRNA expression by in vitro transfection of hepatitis B virus X tuclazepam gene into human hepatocarcinoma and cholangiocarcinoma cells. World J Gastroenterol 2005, 11:5627–5632.PubMed 25. Su JM, Lai XM, Lan KH, Li CP, Chao Y, Yen SH, Chang FY, Lee SD, Lee WP: X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter. Hepatology 2007, 46:402–413.PubMedCrossRef 26. Zhang X, Dong N, Zhang H, You J, Wang H, Ye L: Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells. J Lab Clin Med 2005, 145:98–104.PubMedCrossRef 27. Zou SQ, Qu ZL, Li ZF, Wang X: Hepatitis B virus X gene induces human telomerase reverse transcriptase mRNA expression in cultured normal human cholangiocytes. World J Gastroenterol 2004, 10:2259–2262.PubMed 28.