Implant reconstruction involves identification of the needle tips and the needle path accurately. “Tip location” positions the needle in the cranial–caudal direction and thus determines the location of the source dwell positions relative to the

anatomy in the treatment plan. Others have studied the accuracy of needle tip PS-341 mw identification (9) and have found the locations of needle tips in general to be accurate; however, their study was idealized in that they were identifying individual needle tips inserted one at a time into a water bath. In practice, the challenge is to identify needle locations in a geometric arrangement of multiple needles. Needle tip location in this phantom study was determined to have median difference of 0.5 mm (range, −5.8–3.4 mm) compared with the CT-based tip location.

The median difference is reassuringly small and most differences were less than 2.0 mm (Fig. 6); however, the magnitude of the outlying discrepancies is clearly unacceptable. Although misidentifying the tip of a small number of needles per implant did not have as large a negative impact on overall dosimetry as the systematic shift in needle channel positions did, this error will result in local dosimetric changes that may be important if the planned dose cloud surrounding the needle is actually closer to OAR structures or farther from target structures. There are a number of strategies that can be used to mitigate this problem. As difficulty in identifying needle tip location is increased when the needle under consideration TSA HDAC concentration falls in the shadow of a more posterior needle, one possibility is to track

and identify the tips of the more anterior needles first. This can be accomplished by observing the tips using longitudinal US images as the needle is advanced to its final position. The Vitesse (Varian) software has tools that aid in doing this and allow one to lock down the tip position of each needle as it is identified. Care must be exercised, however, to ensure that the needles do not move once the tip has been identified. Measuring the lengths of the needles that protrude from the implant template can provide a check that the needles have not moved and ameliorate difficult needle tip identifications. Knowing this length, it would be possible, using knowledge of the Thiamet G physical location of the TRUS transducer with respect to some external mark on the probe, to determine exactly where the needle tip was with respect to the plane of the TRUS transducer. In practice, however, it is more practical to use the measured lengths of the protruding needles to determine the tip locations relative to one of the lower needles that are well visualized in the image. This technique was applied to the needles in the phantom study, and this reduced the maximum error in the cranial–caudal direction from 5.8 to 1.9 mm.