Ford et al. (2007) 20 (65 %; 13) Above average risk Focus groups were conducted to determine factors influencing perceptions of breast selleck chemicals cancer genetic counseling. Factors (background, cognitive/psychosocial, social, and systematic) influencing perceptions of breast cancer genetic counseling. AfAm women who received counseling believed they had a “small
chance” of developing breast cancer, and believed that changes in lifestyle activities could reduce likelihood of developing the disease. Halbert, PND-1186 clinical trial Brewster et al. (2005) 164 (100 %) 5–10 % probability of having a BRCA1/2 mutation Evaluated the process of recruiting AfAm women into genetic counseling. Women completed baseline interviews followed by genetic counseling prior to genetic testing. Perceived risk of BRCA1/2 mutation, genetic counseling uptake. Referral from oncology clinics was the only factor
significantly associated with participation find more in genetic counseling; no association between perceived risk and genetic counseling uptake. Halbert, Kessler et al. (2005) 141 (100 %) 5–10 % probability of having a BRCA1/2 mutation Examined cancer-specific distress in AfAm women at an increased risk of hereditary breast and ovarian cancer Distress, history of cancer and avoidance. AfAm women aged 50 and younger, those who are unemployed and women with a personal history of breast or ovarian cancer may be the most vulnerable to experiencing elevated levels of distress during genetic counseling and testing. Halbert, Kessler, Stopfer et al. (2006) 157 (100 %) 5–10 % probability of having a BRCA1/2 mutation Investigated acceptance rates of genetic testing results among AfAm women at increased risk for breast cancer. Perceived risk of BRCA1/2 mutation, perceived certainty of risk, worry, genetic testing result acceptance. Women with higher pre-testing beliefs about the probability of being a mutation carrier and those
who had less certain beliefs about the certainty of developing cancer were more likely to accept medroxyprogesterone genetic test results. Halbert et al. (2010) 198 (100 %) Minimum 5 % probability of having a BRCA1/2 mutation RCT of genetic counseling and testing (2003–2006) to evaluate effects of genetic counseling and testing in AfAm based on different levels of exposure: (a) women who were randomized to culturally tailored (CTGC) and standard genetic counseling (SGC) to women who declined randomization (non-randomized group); (b) participants and non-participants in genetic counseling; and (c) BRCA1/2 test result acceptors and decliners. Perceived risk of developing breast cancer and cancer worry. Women randomized to CTGC and SGC did not differ in terms of changes in risk perception and cancer worry compared to decliners. Hughes, Gomez-Caminero et al.