Due to their immunosuppressive and reparative properties MSC immunotherapy constitutes an attractive intervention for chronic rejection,
while avoiding the undesired adverse effects associated with excessive use of immunosuppressive drugs.
Recent findings
The immunoregulatory properties of MSCs in both cellular and antibody-mediated Vadimezan molecular weight inflammatory models and diseases have highlighted their potential to treat chronic rejection after SOT. Moreover, MSCs can also induce tissue regeneration and repair due to their antifibrotic and angiogeneic properties. Studies in experimental animals after SOT support the potential for MSCs to treat or prevent ongoing alloreactivity and the first clinical trials in transplant recipients are underway.
Summary
MSCs are arising as promising cellular immunotherapy in transplant recipients and carry the potential to prevent or reduce the consequences of chronic or ongoing alloimmune injury.”
“Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic MAPK inhibitor nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Methods. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin excretion, creatinine clearance, renal histologies,
acetylated-NF-kappa B (p65), Sirt1 protein expression, and p62/Sqstm1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes
in proximal tubular cells were estimated. Results. DR ameliorated renal abnormalities including inflammation in WFRs. The SB203580 cell line decrease in Sirt1 levels, increase in acetylated-NF-kappa B, and impaired autophagy in WFRs were improved by DR. Conclusions. DR exerted antiinflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes.”
“First principles calculations based on the spin density functional theory are performed to study the electronic and magnetic properties and also the band alignment of zb-CrSb/Ga0.87In0.13As (001) heterojunction. Our results show that half metallicity persist at the interface. The calculation of band alignment in the heterojunction implies that in the Cr/As and Sb/Ga junctions, the Fermi level lies above the conduction band minimum (CBM) of Ga0.87In0.13As, and CBM of the minority spin lies just above that of Ga0.87In0.13As, suggesting that the majority spin can be injected into Ga0.87In0.13As without being flipped to the conduction bands of the minority spin. Thus the CrSb/Ga0.87In0.13As heterojunction can be potentially useful in the field of spintronics.