Design-Retrospective case series.

Animals-101 horses with navicular syndrome.

Procedures-Medical records of horses with signs of navicular syndrome evaluated between January 2000 SBE-β-CD and December 2008 were reviewed. Data on signalment, use of the horse, history, affected limbs, duration of lameness, findings on lameness examination, radiographic findings, MRI findings, treatment, and outcome were collected from

the medical records. Follow-up information was obtained a minimum of 10 months after navicular bursa injection.

Results-Following navicular bursa injection, 76 of 101 (75%) horses returned to their intended use for a mean of 9.66 months, and 35 (35%) were sound at follow-up. Horses that had been lame for < 6

months before treatment were significantly more likely to return to their intended use, have a longer positive response to treatment, and be sound at follow-up, compared with horses that had a longer lameness history. Horses with primary deep digital flexor (DDF) tendonitis responded best to navicular bursa injection with rest and rehabilitation, followed by horses with navicular bursitis and horses with DDF tendonitis and adhesions to the collateral sesamoidean ligament of the distal sesamoid (navicular) bone. Horses with scar tissue in the proximal portion of the navicular bursa, adhesions from the navicular bone to the DDF tendon, or multiple abnormalities did not respond as well to treatment

Conclusions and Clinical Relevance-Response to navicular bursa injection with corticosteroid and hyaluronan in horses with navicular syndrome was dependent on the disease process detected NVP-LDE225 on MRI and duration of lameness. (J Am Vet Med Assoc 2012;241:1353-1364)”
“The high atomic number of some superconducting elements such as niobium (Z = 41) and

tantalum P-gp inhibitor (Z = 73) and a high material thickness (e.g., t = 300 mu m) are emphasized as essential properties for development of a gamma-ray solid state detector with high intrinsic detection efficiency in the energy range up to 100 keV. To exploit these properties, a new detection principle based on the interaction of a single gamma-ray photon with Abrikosov vortex is proposed. The interaction of gamma-ray photon with a superconductor is discussed in terms of the photoelectric absorption and a hot-spot formation, the last acts as a short-time pinning center on an Abrikosov vortex and activates its motion, namely, a jump or damped vibration. Both types of vortex motion lead to variation (either static or dynamic) in the magnetic field on the absorber surface. The high sensitivity of the Josephson tunneling to weak magnetic field can be exploited for revealing the magnetic field variation and to make the readout of the detector. Main intrinsic properties of a gamma-ray detector based on Abrikosov vortices are evaluated, including the possibility to measure the energy deposited in the detector.