Combined therapy with vancomycin and meropenem or imipenem gave the most effective treatment against Gram-positive and Gram-negative isolates based on empirical therapy. High frequencies of multiresistant bacteria in ICUs warn its to administer a few effective antibiotics in our hospitals more wisely in order to reduce selective pressure on sensitive strains. This could help save the life of ICU patients and prevent of spread of resistant isolates in these critical wards. Due to continuous changes in antibacterial susceptibility
patterns, periodical antibacterial sensitivity assessment in ICUs should be mandatory.”
“Weight regain after gastric bypass (GBP) can be associated with a gastrogastric fistula (GGF), in which a channel forms between the gastric pouch Bucladesine inhibitor and gastric remnant, allowing nutrients to pass through the “”old route”" rather than bypassing the duodenum. To further understand the mechanisms by which GGF may lead to weight regain, we investigated gut hormone levels in GBP patients with a GGF, before and after repair.
Seven post-GBP
subjects diagnosed with GGF were studied before and 4 months after GGF repair. Another cohort of 22 GBP PD173074 nmr control subjects without GGF complication were studied before and 1 year post-GBP. All subjects underwent a 50-g oral glucose tolerance test and blood was collected from 0-120 min for glucose, selleck chemicals insulin, ghrelin, PYY3-36, GIP, and GLP-1 levels.
Four months after GGF repair subjects lost 6.0 +/- 3.9 kg and had significantly increased postprandial PYY3-36 levels. After GGF repair, fasting and postprandial ghrelin levels decreased and were strongly correlated with weight loss. The insulin response to glucose also tended to be increased after GGF repair, however no concomitant increase in GLP-1 was observed. Compared to the post-GBP group, GLP-1 and PYY3-36 levels were significantly lower before GGF repair;
however, after GGF repair, PYY3-36 levels were no longer lower than the post-GBP group.
These data utilize the GGF model to highlight the possible role of duodenal shunting as a mechanism of sustained weight loss after GBP, and lend support to the potential link between blunted satiety peptide release and weight regain.”
“Aim: The aim of the present study was to establish Thai-specific reference ranges of triple markers for fetal Down syndrome as a function of gestational age as well as weight correction models and to compare the false positive rates when using Thai-specific model relative to Caucasian-specific model.
Material and Methods: A total of 993 normal Thai pregnant women were determined for mid-trimester serum levels of alpha-fetoprotein (AFP), free-beta human chorionic gonadotropin (hCG), and unconjugated estriol (uE3), using DefiaXpress system (Perkin Elmer, Waltham, MA, USA).