Clinical use of some of these approaches was promising, but they aren’t trusted on account of a few limitations. Hypoxia inducible factor 1 is really a transcription factor that’s triggered by hypoxia and induces the expression of various genes related to the version of cellular kcalorie burning to hypoxia, invasion and metastasis of angiogenesis and cancer cells, and therefore forth. HIF 1 is a target to boost the therapeutic effects of radiation therapy. Lapatinib HER2 inhibitor Still another approach is antiangiogenic therapy. ?e combination with radiation therapy is encouraging, but several factors including surrogate guns, timing and duration, and so forth need to be enhanced before introducing it into centers. Within this review, we examined how the tumor microenvironment influences the effects of radiation and how we can increase the antitumor effects of radiation therapy by modifying the tumor microenvironment. How radiation therapy shows anti-tumor effects is very important in understanding the relationship between the microenvironment and radiation therapy. Cytotoxicity due to radiation is generally attributed to damage to genomic DNA which includes all the genetic Lymph node instructions for the development and characteristics of all living creatures. Light can affect atoms and/or compounds within the cells and produce free radicals. Since free radicals are highly reactive, they hurt genomic DNA, leading to cell death. ?is can be a so-called indirect action of radiation. On the other hand, when radiation is directly absorbed by DNA, the atoms in the DNA are ionized and damaged. ?it is a so called direct action of light. Whether radiation functions directly or indirectly is dependent upon the linear energy transfer of radiation, that will be the energy transferred per unit length of course. ?e direct action is prominent with hefty charged ion beams whose LETs are high. Meanwhile, about two-thirds of the biological damage due to X, rays, and proton beams is caused by indirect action since their LETs are low. ?except for weighty charged ion beams, harm to genomic DNA is mainly due to the indirect effects Ubiquitin conjugation inhibitor of free radicals and becomes permanent within the presence of air. ?erefore, tumor hypoxia and angiogenesis, which influence tumor hypoxia, have been extensively studied in order to increase the antitumor effects of radiation therapy. That Affect the Therapeutic Effect of Radiation Therapy?e microenvironment of malignant solid tumors is completely different from that of normal tissues, being seen as a marked diversities in pH, the distribution of nutritional elements, and oxygen concentrations, and therefore forth. To know this heterogeneity is very important in cancer radiation therapy because it influences the aftereffect of ionizing radiation through different mechanisms as described in these. Considering that the tumor microenvironment is a unique function, it could be a potent target for cancer treatment.