Both of these studies exhibited significant positive association with SCCHN risk among non-Hispanic white subjects and the south Indian population, respectively [44, 62]. Correspondingly, in the current study, a statistically significant 1.5 or more-fold increase in SCCHN risk was associated with all the mutant genotypes of rs13181 (ERCC2), viz. homozygous mutant (CC) (OR 1.680, 95% CI 1.014 to 2.784, P = 0.0497), heterozygous (AC) (OR 1.531, 95% CI 1.092 to 2.149, P = 0.0167) and combined mutant (AC + CC) (OR 1.560, 95% CI 1.128 to 2.158, P = 0.0073) genotypes. Odds ratios adjusted
against gender or habits (smoking, tobacco chewing and pan masala) using logistic regression also corroborated with the findings made using crude odds ratios only in terms of association of these potential risk factors with significant SCCHN risk demonstrating this website a potential
role of these factors towards SCCHN susceptibility Conclusion The results of the present investigation indicate that the polymorphism rs13181 might be a risk factor for predisposition towards SCCHN and Breast cancer among north Indian subpopulations. The data generated from this study may have wide-ranging applications for further epidemiological and public health related research on the Indian population. learn more The degree of susceptibility to cancers is hypothesised to be the final product of a mishmash of high-risk ROS1 genetic polymorphic variants or SNPs in a subset of medium and low penetrance genes like DNA repair genes which, even in the absence of the highly penetrant variant cancer-associated alleles, may increase the degree of susceptibility towards cancers a few fold thus having a major impact on the population incidence of cancer [19]. Therefore, further initiatives towards the discovery of cancer susceptibility SNPs in other genes involved in the NER pathway and the unravelling of the functional aspects of interactions
between SNP alleles shall be highly beneficial to interpret these potentially meaningful differences that may be cancer-causing and should therefore be vital for revealing the probable synergistic effect of gene-gene and gene-environment interactions in cancer susceptibility. Acknowledgements AKM is a recipient of Senior Research Fellowship from Council of Scientific and Industrial Research, India. NS was a Women Scientist of Department of Science and Technology, Govt. of India. The work was also supported by CSIR network project NWP0034. This paper bears communication number 7677 of CDRI. References 1. Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature 2001, 411: 366–374.CrossRefPubMed 2. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991, 51: 6304–6311.PubMed 3.