9% as compared to 20. 1% for those with normal levels of T. Low levels of T were defined as a level of total T below 250 ngdL or a level of free T below 0. 75 ngdL. This raises the possibility that the HTLD protocol for preventing PC might also result in increased longevity for men. It is not yet selleck chem known what the relationship between T and longevity is for Inhibitors,Modulators,Libraries women. More research is needed to fully identify all beneficial and detrimental effects that may result from using the HTLD protocol in men and in women. In summary, the protocol for preventing both BC and PC involves obtaining Inhibitors,Modulators,Libraries gender appropriate maximum safe physiological levels of bioavailable T, maximum safe physiological level of calcitriol, minimum safe physiolog ical level of DHT and normal level of E2.

Maximum safe physiological levels Inhibitors,Modulators,Libraries of P should be added except for those individuals whose genetic makeup would not benefit from P. If further research should determine that E3 is helpful, then maximum Inhibitors,Modulators,Libraries safe physiological levels of E3 should be added. Also, ingesting large quantities of foods which are known to bind to ER ? with less than full ago nism should be avoided. Other factors, such as nutritional supplements or lifestyle changes which are shown to reduce the incidence of BC and PC, can also be included. Table 3 shows the effects of the HTLD protocol. It is possible that the HTLD protocol might be ineffective or even harmful depending on the mutations that may be in some of the BC or PC already present. For example, if there is a mutation in PC that prevents mAR from upreg ulating apoptotic proteins but still allows it to upregulate bcl 2, then the HTLD protocol would be harmful.

The ear in the PC cell lines LNCaP and DU 145. Although in using the HTLD protocol for preventing PC, the hormones would be Inhibitors,Modulators,Libraries kept within physiological levels, there is still the possibility that long term use of this pro tocol may have some health consequences unrelated to PC. Lean elderly men and women who have Alzheimers disease had lower bioavailable levels of T than those without AD. This might be due to AD causing a drop in the level of bioavailable http://www.selleckchem.com/products/GDC-0449.html T, or by the low bioavailable level of T increasing the likelihood of developing AD. T downregulated ? amyloid peptides in vitro, and ? amyloid is considered to be crucial in the pathogenesis of AD. This increases the likelihood that the decreased levels of bioavailable T were responsible for the increased incidences of AD. If so, then the HTLD protocol for pre venting BC and PC may also be helpful in preventing AD. lier this protocol is started, the less likely that any such adverse mutations would be present.