07; 95% confidence interval [CI], 0.91-1.27; P=0.414; I-2 = 0.0%) and ARC definite and/or probable ST (RR, 1.06; 95% CI, 0.66-1.70; P= 0.810; I-2 = 4.8%). Furthermore, there was no difference in all-cause mortality (RR, 1.06; 95% CI, 0.84-1.33; P= 0.651; I-2 = 0.0%), myocardial infarction (RR, 1.12; 95% CI, 0.88-1.44; P= 0.360; I-2 = 0.0%), and MACE (RR, 1.00; 95% CI, 0.87-1.15; P= 0.975; I-2 = 0.0%) between the two groups. Conclusions The new generation of biodegradable polymer stents were not inferior to EES for equivalent risk of MACE and ST.”
“Background: Localized PKC inhibitor radiotherapy is long known to cause damages

to not only targeted but also non-targeted cells, the so-called bystander (BS) effect. Recently, BS effect was demonstrated in response to chemotherapy. To get further insight into the mechanism of chemotherapy-induced BS effect in vivo, we investigated the response of normal tissues and untreated BS melanomas, at distance from localized chemotherapy-treated melanomas. Methods: 816 melanoma cells were inoculated sc in one flank, in mice. Chemotherapy was administered intratumorally. After 3 weeks, untreated melanomas were implanted into the other flank. Tumors were analyzed morphologically, and using metabolomics and transcriptomics. Results: Locally-treated melanomas showed growth inhibition and pleiotropic metabolic and transcriptional alterations.

see more Tumors recovered slow proliferation while exhibiting prominent oxidative stress response (decreased glutathione level, and increased expression of genes including Mt1, Gpx3, Sod3, and Hmox1). Plasma contained increased levels of oxidative stress products. However, liver and soleus muscle displayed unaltered morphological characteristics. In contrast, untreated BS melanomas induced from naive B16 cells showed reduced growth, marked oxidative stress response (decreased glutathione level, and increased expression of genes including Sod2, Gpx1 and Gsr), and ras oncogene

Proton Pump inhibitor expression alterations. Furthermore, metabolomics and transcriptomics enabled to estimate the proportion of cells undergoing the BS effect within treated tumors. Conclusion: Treatment of tumors with chemotherapy induces BS effects, underpinned by oxidative stress, in abnormal proliferating tissues in vivo, not in normal tissue, that significantly contribute to overall tumor response. General significance BS effect significantly contributes to response to chemotherapy, and may be exploited to improve overall response to cancer treatment. (C) 2013 Elsevier B.V. All rights reserved.”
“Aging is associated with changes in body composition and muscle strength. This review aimed to determine the relation between different body composition measures and muscle strength measures and functional decline in older men and women.