05) (Table 1). The mean pre-operative QOL was 4.3 ± 0.7, while it was 1.15 ± 0.8 at 3 months and 1.3 ± 0.6 at 12 months postoperatively, which was a statistically significant difference between pre- and postoperatively at both 3 months (P < 0.01) and 12 months (P < 0.01), but the difference between 3 and 12 months
postoperatively was not statistically significant (P < 0.05) (Table 1). The mean pre-operative RU was 85.6 ± 6.0 mL while it was 25.6 ± 8.5 mL at 3 months and 27.1 ± 8.5 mL at 12 months postoperatively. The difference between pre-operative RU and postoperative both at 3 months (P < 0.01) and 12 months (P < 0.01), but the difference Selleckchem Epigenetics Compound Library between 3 and 12 months postoperatively was not statistically significant (P < 0.05) FK506 (Table 1). According to the result of statistical analysis, which was summarized in Table 1, the patients become asymptomatic. Maximum urinary flow rate rose up to its normal range, good quality of life ensued, and no significant post-voiding residual urine appeared. This result indicates that TV pedicle flap urethroplasty is a safe and successful
procedure for patients with anterior urethral stricture. There were few changes in clinical parameters between 3 and 12 months postoperatively, but the differences were not statistically significant. An early postoperative complication was one case of wound infection and subsequent wound dehiscence in tabularized technique and also one case of hematoma formation in ventral onlay technique. Wound infection was resolved by 2-weeks of antibiotic therapy and the hematoma was drained. In one patient on the tabularized technique, re-stricture developed, while in the onlay technique, one case of urethro-cutaneous occurred.
Both of them were considered failed cases. There was no other complication like penile curvature (chordee) in our series. The total success rate in our study was 86.6% (13/15). oxyclozanide There was no statistically significant difference between success rate of tabularized and ventral onlay technique. A great variety of tissues from the genital and extra genital area have been tried both experimentally and clinically for a flap or free graft. These include the fasciocutaneous component of the penis, bucal mucosa graft, vesicle mucosa, small intestinal sub-mucosa and peritoneum.[4] Besides that, several surgical techniques have been launched to find an ideal substitute for the urethra, but it seems that the ideal graft or flap has not been identified yet. Based upon many previous experimental studies, we clinically evaluated the feasibility and usefulness of tunica vaginalis pedicle flap for reconstruction of anterior urethral stricture in the form of ventral onlay and tabularized techniques. Our sample comprised 15 adult men with bulbo-penile acquired urethral stricture, of which nine underwent TV-ventral onlay and six underwent TV-tubularized urethroplasty.