Results: As compare with vehicle-treated animals, empagliflozin-treated OLETF rats showed approximately 1,000-fold increase in
urinary glucose excretion and improved glucose metabolism. Furthermore, empagliflozin significantly decreased blood pressure, which was associated with increases in urinary excretion of sodium. Conclusion: These data suggest that empagliflozin elicits beneficial effects on glucose metabolism and hypertension in salt-treated obese metabolic syndrome rats. WU VIN-CENT1, HUANG TAO-MIN2 1National Taiwan University Hospital; Selleckchem Kinase Inhibitor Library 2National Taiwan University Hospital, Yun-Lin Branch Introduction: The incidence rate of acute kidney injury (AKI) in hospitalized patients is increasing. However, relatively little attention has been paid to association of AKI with long-term risk of adverse coronary events. Methods: Our selleck compound study investigated hospitalized patients who recovered from de novo dialysis-requiring AKI between 1999 and 2008. Their data were collected from inpatient claims of the Taiwan National Health Insurance (NHI). We used Cox regression with time-varying covariates to adjust for subsequent chronic kidney disease (CKD) and end-stage renal disease (ESRD) after discharge. Results
were further validated by analysis of a prospectively constructed database. Results: Among the 17,106 acute dialysis patients who were discharged, 4,869 recovered from dialysis-requiring AKI (AKI-recovery group) and were matched with 4,869 non-AKI patients. The incidence rates of coronary events were 19.8 and 10.3 per 1,000 person-years in the AKI-recovery and the non-AKI groups, respectively. AKI-recovery was associated with higher risk of coronary events (hazard ratio (HR), 1.67) and all-cause mortality (HR, 1.67), independent of the effects of subsequent progression of CKD and ESRD. The risk levels of de novo coronary events after hospital discharge were close in those with diabetes alone and AKI alone (p = 0.227). Conclusion: Our study results reveal that AKI with recovery was Farnesyltransferase associated with higher long-term risks of coronary events and death, suggesting that AKI could be added into the list
of criteria identifying patients with high risk of future coronary events. It may be warranted to enhance post-discharge follow-up of renal function, even among patients who have recovered from temporary dialysis. MARBA IAN LEE V. Chong Hua Hospital, Cebu Introduction: Contrast-induced nephropathy is now established as the third most common cause of hospital acute kidney injury after surgery and hypotension. With the increase in numbers of PCI performed in the tertiary hospitals in the country, institution may apply a scoring system that will predict the risk of CIN and dialysis. Hence, this local study was conducted to validate the Mehran score in predicting CIN after PCI and used this scoring system as part of the hospital quality improvement goal.